Replacement of Microscopy Core 10-years-old Zeiss LSM-510 with a new LSM-710

描述（由申请人提供）：宾夕法尼亚大学医学院细胞与发育生物学系于2006年建立了显微镜核心设施。核心的使命是培训和协助生物医学科学家，无论是部门和大学范围内，在显微镜的应用，他们的研究。核心的日常活动由Andrea Stout博士（主任）和Yuri Veklich博士（经理）监督。用户使用核心的工具需支付少量费用。反过来，产生的资金又作为设备服务合同、供应品或斯托特博士和维克利奇博士的工资支持投入核心。核心在一个行政屋顶下汇集了几台显微镜，其中的中心部分是1998年由NIH SIG资助购买的蔡司LSM-510激光扫描共聚焦显微镜（PI：John Murray博士）。这台显微镜已经工作了10多年，为30多个NIH资助的实验室的研究做出了贡献，并直接导致了100多篇出版物。由于过去十年的正常磨损，这台显微镜不再以最佳效率运行，某些部件不再由制造商支持。我们现在请求资金，以将LSM-510更换为当前版本的LSM-710。新的显微镜将确保研究人员的持续使用和生产力，从而保持工作安全和Stout和Veklich博士的显微镜培训使命。

DESCRIPTION (provided by applicant): The Department of Cell & Developmental Biology of the University of Pennsylvania School of Medicine established a Microscopy Core facility in 2006. The mission of the Core is to train and assist biomedical scientists, both departmental and University-wide, in the application of microscopy to their research. The daily activity of the Core is overseen by Dr. Andrea Stout (Director) and Dr. Yuri Veklich (Manager). Users are charged a modest fee for the use of the instruments of the Core. In turn, the money generated is put back into the Core as equipment service contracts, supplies, or salary support for Drs. Stout and Veklich. The Core brought together several microscopes under one administrative roof, the center piece of which is a Zeiss LSM-510 laser scanning confocal microscope purchased in 1998 with a NIH SIG grant (PI: Dr. John Murray). This microscope has been a work-horse for more than 10 years, has contributed to the research of more than 30 NIH-funded laboratories, and has directly resulted in over 100 publications. Due to normal wear-and-tear during the past ten years, this microscope is no longer operating at optimal efficiency and some parts are no longer supported by the manufacturer. We now request funds to replace the LSM-510 with its current version LSM-710. The new microscope will ensure continued usage and productivity from the researchers, and thus maintain job security and microscopy-training mission of Drs. Stout and Veklich.