Upgrade of the Stanford GE-Varian Experimental MRI Scanner to the Current Model M

描述（由申请人提供）：本提案是对NCRR“共享仪器计划10”（RFA：PAR-09- 028）的回应，旨在加强我们对改进仪器的投资，以促进斯坦福大学跨学科项目的生物医学研究。转化生物医学研究是当今最重要的，随着分子医学和干细胞的快速发展，在与公共卫生的相关性方面发挥着至关重要的作用。我们正在申请资金，将我们的通用电气医疗保健公司的“MicroSigna”7特斯拉/310毫米动物MRI扫描仪升级为最近宣布的GE-瓦里安产品MR 901。斯坦福大学7 T MicroSigna于2005年从受资助的NCRR NIH高端共享仪器赠款（1 S10 RR 019887 -01）购买，标题为“高场GE实验MR扫描仪”。从S10机构购买的现有MicroSigna 7 T实质上是现在产品MR 901的商业原型。收购拟议的通用电气-瓦里安MR 901 7特斯拉高场小口径MR扫描仪升级将完成我们对MR实验扫描仪的需求，以支持和推动我们的多模态成像设施（斯坦福大学小动物成像中心（SAIC））内的基础和临床科学家社区的研究。SAIC得到了斯坦福大学NCRR P41（格洛弗，PI）、斯坦福大学的斯坦福大学分子成像项目（MIPS，Contag，PI）和斯坦福大学体内细胞和分子成像中心（ICMIC，Gambhir，PI）的支持。即将获得的MR升级将使我们能够更好地非侵入性地监测小动物模型的结构和功能变化。SAIC内最先进的MR成像对于提高检测灵敏度和分辨率是必要的;我们在P41内强大的MR导向教师帮助我们开发新的MR应用，以支持越来越多的关键生物医学实验研究，这些研究现在正在我们的3 T和7 T全身GE Signa LX扫描仪上进行。收购这一新的实验扫描仪升级将带来最好的临床控制台（Signa HDx 20 x，多线圈平台）和所有斯坦福衍生的Signa脉冲序列一起进入最近宣布的GE-Varian MR 901 MR扫描仪商业产品线。目前的GE 7 T动物扫描仪（“MicroSigna”）无疑增强了我们在斯坦福大学的MR项目，为自上而下的转化研究提供了一条途径，即将临床研究扫描仪上可用的所有MR工具引入我们的常规动物扫描。此次升级是为了进一步改进我们的成像技术，并使我们的MR扫描仪成为GE和Varian完全支持的产品，从而极大地促进了研究人员和年轻研究人员对最先进的MR成像的了解，并支持强大的多模态斯坦福大学小动物成像设施（SAIC）。 公共卫生相关性：该提案旨在为斯坦福大学小动物成像设施（SAIC）和斯坦福大学研究团体收购通用电气-瓦里安MR 901 7特斯拉高场小口径MR扫描仪升级。SAIC内现有的GE 7 T动物扫描仪（“MicroSigna”）虽然允许我们的许多主要和次要小组启动MR研究计划，但受到此次升级将解决的几个因素的限制。MRI扫描仪和梯度线圈升级将使我们能够更好地监测我们各种实验模型的结构和功能变化。此次升级还将使我们的MRI扫描仪达到当前商业产品的潜力，这对于任何和所有未来的增强都是必要的。斯坦福大学最先进的磁共振成像是必要的，以提高检测灵敏度和分辨率，我们可以实现我们目前的系统。

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "SHARED INSTRUMENTATION PROGRAM S10" (RFA: PAR-09- 028) to reinforce our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs. Translational biomedical research is of the utmost importance today and with the rapid advances in molecular medicine and stem cells, plays a vital role in the relevance to public health. We are requesting funds for an upgrade of our General Electric Healthcare "MicroSigna" 7 Tesla/310mm animal MRI scanner to the recently-announced GE-Varian product, the MR901. The Stanford 7T MicroSigna was purchased in 2005 from a funded NCRR NIH High-End Shared Instrumentation Grant (1 S10 RR019887-01) entitled "High Field GE Experimental MR Scanner". The existing MicroSigna 7T purchased from the S10 mechanism was in essence a commercial prototype of the now product MR901. The acquisition of the proposed General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade will complete our needs for an MR experimental scanner to support and drive the research of our community of basic and clinical scientists within the multimodality imaging facility, the Stanford Small Animal Imaging Center (SAIC). The SAIC is supported by the Stanford NCRR P41 (Glover, PI), the Stanford Molecular Imaging Program at Stanford (MIPS, Contag, PI), and the Stanford In Vivo Cellular and Molecular Imaging Center (ICMIC, Gambhir, PI). The MR upgrade to be acquired will permit us to better monitor both structural and functional changes in small animal models non-invasively. State of the art MR imaging within the SAIC is necessary to enhance detection sensitivity and resolution; our strong MR-oriented faculty within the P41 has helped us develop new MR applications to support a growing number of crucial biomedical experimental studies now being done on our 3T and 7T whole-body GE Signa LX scanners. The acquisition of this new experimental scanner upgrade will bring the best in clinical consoles (the Signa HDx 20x, multi-coil platform) and all Stanford-derived Signa pulse sequences together into the recently announced GE-Varian MR901 MR scanner commercial product line. The current GE 7T animal scanner (the "MicroSigna") has no doubt enhanced our MR program at Stanford by providing a route for translational research from the top down, that is, by bringing all the MR tools available on clinical research scanners to our routine animal scanning. The upgrade is needed to further improve our imaging technology and bring our MR scanner to a product fully supported by GE and Varian and thus greatly facilitate the introduction of researchers and young investigators to state-of-the-art MR imaging, and also support a strong multi-modality Stanford Small Animal Imaging Facility (SAIC). PUBLIC HEALTH RELEVANCE: This proposal seeks the acquisition of the General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade for the Stanford Small Animal Imaging Facility (SAIC) and the Stanford research community. The current GE 7T animal scanner (the "MicroSigna") housed within the SAIC, while having allowed our many major and minor groups to initiate MR research programs, is limited by several factors which this upgrade will address. The MRI scanner and gradient coil upgrade will permit us to better monitor both structural and functional changes in our various experimental models non-invasively. The upgrade will also bring our MRI scanner to the current commercial product potential necessary for any and all future enhancements. State of the art MR imaging at Stanford is necessary to enhance detection sensitivity and resolution over what we can achieve today on our present system.