600 MHz nuclear magnetic resonance spectrometer console

描述(由申请人提供)：沃兹沃斯中心的一组研究人员正在申请资金，以购买Bruker Avance III 600 MHz核磁共振光谱仪控制台。该仪器的主要用户包括NIH资助的三个现有实验室和两个以前和即将建立的实验室。申请的核磁共振控制台旨在取代已有15年历史的控制台，其组件的功能可靠性已大幅恶化。在其整个生命周期中，我们目前的600 MHz核磁共振控制台为从NIH招募和成功执行11项不同的R01拨款以及支持生物医学研究的另外3项联邦拨款做出了重要贡献。随着我们当前控制台的可靠性恶化，供应商提供的替换组件的可用性进一步减少，沃兹沃斯中心核磁共振相关研究的科学生产力的持续保持将受到严重影响。所需的Bruker Avance III 600 MHz核磁共振控制台将提供推进沃兹沃斯中心生物医学核磁共振研究计划所需的仪器性能。此外，这个最先进的核磁共振控制台提供的20%的灵敏度提高和更广泛的实验能力将促进我们机构提高科学生产率。该仪器将被整合到一个长期存在的核磁共振核心设施中，由地方行政和监督委员会确保适当的使用和维护。沃兹沃斯中心坚定地致力于更换这个核磁共振控制台，作为其对沃兹沃斯调查人员进行核磁共振研究的总体承诺的一部分。作为支持的证据，该中心将继续提供一名国家资助的、有经验的研究科学家来监督仪器的运行，承担与核磁共振设施的年度服务合同相关的费用，以及购买超导磁体运行所需的液氦和液氮。此外，在时间允许的情况下，该仪器将在专门的核磁共振核心人员的协助下提供给其他受资助的研究人员，从而加强沃兹沃斯中心对核磁共振作为生物医学研究的关键技术的持续承诺。

DESCRIPTION (provided by applicant): A group of investigators at the Wadsworth Center is requesting funds to purchase a Bruker Avance III 600 MHz NMR spectrometer console. The major users of this instrument include three current and two previous and pending NIH-funded laboratories. The requested NMR console is intended to replace a 15 year old console for which the functional reliability of its components has deteriorated substantially. Over the course of its lifetime, our current 600 MHz NMR console has made a central contribution to the recruitment and successful execution of 11 distinct R01 grants from NIH as well as 3 additional federal grants supporting biomedical research. The continued maintenance of scientific productivity in NMR-related research at the Wadsworth Center will be significantly compromised as the reliability of our current console deteriorates and the availability of replacement components from the vendor diminish further. The requested Bruker Avance III 600 MHz NMR console will provide the instrumentational performance that is needed to carry forward the biomedical NMR research programs at the Wadsworth Center. Furthermore, the 20% increased sensitivity and wider range of experimental capabilities that this state-of-the-art NMR console provides will facilitate enhanced scientific productivity at our institution. This instrument will be integrated into a long-standing NMR Core facility, with local administrative and oversight committees to ensure appropriate use and maintenance. The Wadsworth Center is strongly committed to the replacement of this NMR console as part of its overall commitment to NMR research among the Wadsworth investigators. As evidence of support, the Center will continue to provide a State-funded, experienced, Research Scientist to oversee the instrument's operation, assume costs associated with the annual service contract for the NMR facility, and the purchase of the liquid helium and liquid nitrogen required for the operation of the superconducting magnets. In addition, and as time permits, this instrument will be made available to other funded investigators with assistance from the dedicated NMR Core personnel, thus enhancing the Wadsworth Center's continued commitment to NMR as a critical technique for biomedical research.