High Performance Digital NMR Spectrometer Console

描述（由申请人提供）：斯克里普斯研究所的生物分子核磁共振设施是美国最重要的设施之一。在过去的二十年里，斯克里普斯在建造和装备这一设施方面进行了巨大的投资，但许多光谱仪上的电子控制台现在已经过时，需要更换。这项提案要求提供资金，以取代我们最敏感的仪器上过时的1997年老式DRX控制台，这是一台配备低温探头的800 MHz光谱仪，使用最先进的Avance III控制台。新的电子控制台预计将增加仪器的灵敏度高达25%，提供增强的射频生成和相位稳定性，以提高要求苛刻的脉冲实验的性能，并使新的2H弛豫和非线性采样实验的实施，根本不能与我们现有的仪器进行。升级后的电子设备将直接使四个主要用户群体（戴森、威廉姆森、赖特和W| thrich）和两个小用户（Kelly和Otomo）。这些研究项目正在探索结构生物学的基本问题，并解决与人类健康和疾病相关的关键问题。该仪器的增强功能将促进对癌症、强直性肌营养不良、神经变性、淀粉样蛋白疾病和传染病的潜在分子基础的正在进行的和未来的研究。

DESCRIPTION (provided by applicant): The Biomolecular NMR facility at The Scripps Research Institute is one of the foremost in the United States. Scripps has made an extraordinary investment over the past two decades in building and equipping this facility but the electronics consoles on many of the spectrometers are now obsolete and need to be replaced. This proposal requests funding to replace the obsolete 1997-vintage DRX console on our most sensitive instrument, an 800 MHz spectrometer equipped with a cryogenic probe, with a state-of- the-art Avance III console. The new electronics console is expected to increase the sensitivity of the instrument by as much as 25%, provide enhanced radiofrequency generation and phase stability to improve the performance of demanding pulse experiments, and enable the implementation of new 2H relaxation and non-linear sampling experiments that simply cannot be performed with our existing instrumentation. The upgraded electronics will directly benefit the NIH-funded research programs of four major user groups (Dyson, Williamson, Wright, and W|thrich) and two minor users (Kelly and Otomo). These research programs are probing fundamental questions in structural biology and are addressing key issues related to human health and disease. The enhanced capabilities of the instrument will facilitate ongoing and future research on the underlying molecular basis of cancer, myotonic dystrophy, neurodegeneration, amyloid diseases, and infectious disease.