NMR instrumentation: Stanford core facility 800 MHz console

描述(由申请人提供)：斯坦福大学磁共振实验室(SMRL)是斯坦福大学医学院的研究核心设施，为斯坦福大学研究界提供高场核磁共振仪器和专业知识。SMRL正在为老化的瓦里安Inova 800 MHz光谱仪寻找新的控制台，以最好地支持高场研究。已有11年历史的800光谱仪于1998年被斯坦福大学用来刺激高场光谱学的资金购买。当时，它是瓦里安(游戏机)和牛津(磁铁)在世界上生产的第一批四款产品之一。在过去的十多年里，它发挥了很好的作用，支持了NIH资助的大量研究项目。磁铁继续发挥着良好的作用，但游戏机正在显示其老化，电子元件的不稳定性和停机时间增加。通过利用现有设施中的现有800 MHz磁铁，升级光谱仪控制台将为高场用户群带来立竿见影的好处，其成本是全新800 MHz光谱仪系统的四分之一至三分之一，而且不需要任何新的基础设施改进。新的游戏机将立即为SMRL高场NIH资助的用户群(Axel Brunger、Ronald Davis、K.Christopher Garcia、Daniel Herschlag、Brian Kobilka、Roger Kornberg、Merritt Maduke和Joseph Puglisi)的具有挑战性的项目提供最先进的技术。优势包括高度并行的架构、先进的数字滤波算法和全数字接收器，使其能够运行要求最苛刻的高场实验，包括对快速技术、非线性采样方法和多接收器技术的高级支持。高场强核磁共振用户的研究工作范围很广，从研究免疫系统的基本工作原理，到寻求对创伤性痛苦和疾病的生理因素的临床理解，到利用人类疾病的新模型系统，到筛选新药和疗法；这些项目都将从NIH提供的共享仪器资源中受益匪浅。

DESCRIPTION (provided by applicant): The Stanford Magnetic Resonance Laboratory SMRL) is a research core facility in the Stanford University School of Medicine, providing high-field NMR instrumentation and expertise to the Stanford research community. The SMRL seeks a new console for the aging Varian Inova 800 MHz spectrometer in order to best support high-field research. The 11 year old 800 spectrometer was purchased in 1998 by Stanford with University funds to stimulate high field spectroscopy. Then, it was one of the first four produced by Varian (console) and Oxford (magnet) in the world. It has served well for the past decade-plus supporting a plethora of NIH-funded research projects. The magnet continues to function well, but the console is showing its age with increased electronic component instabilities and downtimes. By leveraging an existing 800 MHz magnet in an established facility, upgrading the spectrometer console will provide immediate benefits to the high-field user base at a quarter to a third the cost of a entirely new 800 MHz spectrometer system and without need for any new infrastructure improvements. The new console will immediately provide state-of-the-art technology to the challenging projects of the high-field NIH-funded user base at the SMRL (Axel Brunger, Ronald Davis, K. Christopher Garcia, Daniel Herschlag, Brian Kobilka, Roger Kornberg, Merritt Maduke, and Joseph Puglisi). Benefits include highly parallelized architecture, advanced digital filter algorithms, and full digital receiver, enabling the ability to run the most demanding of high- field experiments including advanced support for fast techniques, non-linear sampling methods, and capability for multiple receiver technology. Research efforts from the high-field NMR users range from studying the fundamental workings of the immune system, to seeking a clinical understanding of the physiological contributors to traumatic distress and disease, to utilization of novel model systems of human disease, to screening for new drugs and therapeutics; projects that will all benefit greatly from the shared instrumentation resource to be provided by the NIH.