Carl Zeiss AxioImager Z1 Research Microscope

描述(申请人提供)：我们正在申请资金，从卡尔蔡司购买一台AxioImager Z1研究显微镜，以更换我们的蔡司荧光Axioplan显微镜，该显微镜在过去15年左右的时间里被大量用户大量使用，显示出相当大的磨损，并且不再提供更换部件和镜头。拟议中的显微镜将由8名用户使用，他们都是肯尼迪·克里格大学雨果·W·莫泽研究所的教员，每个人都是约翰·霍普金斯大学医学院的教员。购买这台显微镜将支持这些研究人员的R01、P01、K奖和非联邦拨款，并将对这些拨款的持续研究进展和生产率至关重要。将利用拟议的显微镜的项目范围很广，从新生儿缺氧缺血、斯特奇·韦伯综合征和其他发育障碍的动物模型，如雷特综合征、自闭症、肾上腺皮质营养不良和其他代谢障碍，到脑癌。这些项目需要复杂和高分辨率的光学和图像分析，拟议的显微镜和附带的软件将提供。授予这一文书将对项目的生产率产生积极影响。显微镜将被安置在由肯尼迪·克里格研究所智力和发育障碍资源中心(IDDRC)(前身为MRDDRC)资助的组织学和成像核心内，并为内部显微镜的培训和维护提供支持。这将提高使用IDDRC核心的本科生和研究生、博士后研究员、工作人员和教职员工的生产力。反过来，这将推动肯尼迪·克里格研究所的使命，即了解发育性残疾的生物学基础，并发现新的治疗方法，以改善在这里接受治疗的儿童的生活和潜力。

DESCRIPTION (provided by applicant): We are applying for funds to purchase an AxioImager Z1 research microscope from Carl Zeiss to replace our Zeiss fluorescence Axioplan microscope, which has been heavily used for the past fifteen or so years by a large number of users, that is showing considerable wear and tear, and for which replacement parts and lenses are no longer available. The proposed microscope will be used by a group of 8 users who are all faculty within the Hugo W. Moser Research Institute at Kennedy Krieger, each with faculty appointments at the Johns Hopkins University School of Medicine. The purchase of this microscope will support these investigators' R01, P01, K awards and nonfederal grants and will be crucial for the continued research progress and productivity of these grants. The projects that will utilize the proposed microscope are broad in scope, ranging from animal models for neonatal hypoxic ischemia, Sturge Weber Syndrome and other developmental disorders, such as Rett Syndrome, autism, adrenoleucodystrophy and other metabolic disorders, to brain cancer. The projects require sophisticated and high resolution optics and image analysis that the proposed microscope and accompanying software will provide. Award of this instrument will have a positive impact on the productivity of the projects. The microscope will be housed within a Histology and Imaging Core that is funded by an Intellectual and Developmental Disabilities Resource Center (IDDRC) (formerly MRDDRC) at Kennedy Krieger Institute, and provides support for training and maintenance for the microscopes within it. This will enhance the productivity of the undergraduate and graduate students, postdoctoral fellows, staff and faculty that utilize this IDDRC Core. In turn, this will advance the mission of the Kennedy Krieger Institute, which is to understand the biological basis for developmental disabilities, and to discover new treatments for enhancing the lives and potential of the children who are treated here.