SARRP 200 Small animal radiation research platform

描述(由申请者提供)：此申请申请资金用于购买宾夕法尼亚大学动物和细胞用的精密X-辐照器/锥束CT。这台仪器(命名为Small Animal Radiation Research Platform-SARRP)是目前任何仪器的重大进步，由约翰·霍普金斯大学的John Wong博士开发，由NCI通过生物工程研究伙伴机制提供支持。SARRP解决了辐射研究中对大鼠和小鼠进行图像引导放射治疗的关键需求，其分辨率和精度可与人类治疗相媲美(按比例比例计算)。所有以前用于动物的仪器都是从用于人类、大型动物或工业的标准辐照器衍生而来的。这些代表着有50年历史的老技术，经过微小的改进。直到这种新机器的开发(由GulMay Medical，Inc.进行商业开发和销售)动物辐射体的射束准直仅限于屏蔽块，而且大多数辐射体没有射束方向的移动自由。目前的仪器具有0.5mm2光束的能力(改进了400倍)，光束方向可以在1200以上变化，并具有基于激光的精确等中心控制。照射阶段有4维运动控制(X-Y-Z和旋转)，允许完全灵活的剂量给药。最重要的是，该仪器被设计为在低功率下运行，作为锥束CT(CBCT)仪器，该仪器的软件是根据人体剂量规划设计的，使用CBCT数据。仪器的软件控制还将允许与其他方式的图像融合，重要的是PET和MRI。该仪器将与其他最先进的成像设备一起使用，最初将安装在约翰·摩根大楼辐射研究部占用的空间，然后转移到宾夕法尼亚大学新的佩雷尔曼高级医学中心。因此，除了为放射肿瘤学部门提供先进的研究能力外，该仪器还将为与宾夕法尼亚大学小动物成像设施的所有其他用户进行联合研究打开一个充满机会的世界。重要的是，由于这种设备的精确度，正常组织研究的许多方面都将成为可能。例如，使用X射线对罗伯茨质子放射治疗中心设计的扫描束系统进行现实比较，并对小鼠肺和脑的特定区域进行选择性照射。 与公共健康相关：这个应用程序请求支持购买一种独特的动物辐射器，名为‘小动物辐射研究平台’(SARRP-GulMay Medical)。该仪器代表了一项独特的、革命性的技术成就，首次允许将最先进的放射治疗提供给小动物(小鼠和大鼠)，以准确地概括用于放射治疗人类癌症患者的参数。这将允许不同领域(放射肿瘤学、放射学、肺部医学等)的研究人员研究辐射对肿瘤和周围正常组织的影响。这项研究将导致更好的方法将辐射传递到目标，减轻正常组织毒性和正常组织在病理出现之前的图像变化，从而改善整体人类健康和生活质量。

DESCRIPTION (provided by applicant): This application requests funds to purchase a precision X-Irradiator/ConeBeam CT for animal and cellular use at the University of Pennsylvania. This instrument (named Small Animal Radiation Research Platform-SARRP) represents a significant advance over any current instrument and was developed by Dr. John Wong at Johns Hopkins University, with support from the NCI through the Bioengineering Research Partnership mechanism. The SARRP addresses a critical need in Radiation Research for Image Guided Radiotherapy in rats and mice with resolution and accuracy comparable (on a scale- proportional basis) to therapy in humans. All former instruments for animal use have been derived from standard irradiators used for humans, large animals or industry. These represent, with minor improvements, 50-yr old technology. Until the development of this new machine (being commercially developed and sold by Gulmay Medical, Inc.) beam collimation for animal irradiators has been limited to shielding blocks and most irradiators had no freedom of movement for beam direction. The current instrument has the capability of 0.5 mm2 beam (a 400-fold improvement) and beam direction can be varied over 1200, with precise laser- based control of isocenter. The irradiation stage has 4-dimensional movement control (X-Y-Z and rotation) allowing complete flexibility of dose administration. Most importantly, the instrument is designed to be operated under low power as a cone- beam CT (CBCT) instrument and software for the instrument is modeled after human dose- planning, using the CBCT data. The instruments software control will also allow image fusion with other modalities, importantly PET and MRI. The instrument will be used in conjunction with other state-of-the art imaging equipment and will be initially installed in space occupied by the Radiation Research Division in the John Morgan Building and later moved to the new Perelman Center for Advanced Medicine at the University of Pennsylvania. Thus, in addition to providing advanced research capabilities for the Radiation Oncology Department, this instrument will open a world of opportunity for combined research with all other users of the Small Animal Imaging facilities at PENN. Importantly, numerous aspects of normal tissue research will become possible due to the precision of this device. Examples include realistic comparisons, using X-rays, of the scanned beam system designed for the Roberts Proton Radiotherapy center and selective irradiation of specific regions of mouse lung and brain. PUBLIC HEALTH RELEVANCE: This application requests support to purchase a unique animal irradiator, named the 'Small Animal Radiation Research Platform' (SARRP - Gulmay Medical). This instrument represents a unique, revolutionary, technical achievement that for the first time allows state-of-the art radiotherapy to be delivered to small animals (mice and rats) to closely recapitulate the parameters used for treatment of human cancer patients with radiotherapy. This will allow researchers in different fields (Radiation Oncology, Radiology, Pulmonary Medicine, etc), to study the effects of radiation on the tumor and surrounding normal tissues. This research will lead to better approaches to deliver radiation to the target, mitigate normal tissue toxicity and image changes in normal tissues before they manifest pathologically, thereby improving overall human health and quality of life.