Clinical and Basic Studies in Male Reproduction

但前提是。 这项建议旨在增加我们对男性生殖生物学和医学的知识和理解。这是基础科学家和临床研究人员之间的多学科合作努力，他们致力于促进我们对生殖生理学和翻译的理解 将这些知识转化为改善人类健康和福祉的知识。拟议的目标包括生殖轴的三个主要分支--下丘脑、垂体和睾丸。拟议的研究包括基础和临床调查，这些调查与了解某些精神障碍有直接关系。 人类生殖，包括特发性性腺激素减退症、雄激素不敏感综合征、减数分裂停滞、仅支持细胞综合征、少精子症或无精子症。我们的临床项目侧重于了解激素和遗传环境对人体健康的影响。 男性的精子发生。基础科学项目研究促性腺激素分泌的神经内分泌控制，血-睾丸屏障的分子基础，以及调节成熟配子发育和功能的关键信号通路。每个项目都涉及与至少一个其他项目在 分子生理学与临床研究相结合。我们相信，这种方法将提供最好的机会，为开发治疗某些生殖障碍的改进疗法提供科学依据，并为开发更好的男性荷尔蒙避孕方案奠定基础。 我们致力于科学的卓越和跨学科的交流，从分子生物学到生理学和医学。我们的建议融合了优秀研究人员的才华，他们的经验和知识代表了生殖生物学及其研究的丰富和广阔的前景。 与人类健康相关。我们精心构建了该中心，将华盛顿大学最优秀和最有成就的生殖生物学家和内科科学家聚集在一起，进行科学合作。我们期待着继续参与美国国立卫生研究院专业合作中心 生殖研究计划(SCCPRR)。我们赞同其促进交流、创新和卓越研究的目标，最终目标是通过加速将在试验台上取得的发现转化为临床实践来改善人类生殖健康。我们致力于SCCPRR的合作精神，并与其他几个机构的SCCPRR项目的调查人员建立了合作关系。我们期待着在这一重要的国家计划中为杰出的临床和基础研究做出贡献。

PROVIDED. This proposal is designed to increase our knowledge and understanding of reproductive biology and medicine in the male. This is a multidisciplinary and collaborative effort among basic scientists and clinical investigators, who are committed to advancing our understanding of reproductive physiology and translate this knowledge into improving human health and well-being. The proposed aims comprise the three major branches of the reproductive axis¿ the hypothalamus, pituitary and testis. The proposed research embraces both basic and clinical investigations, which have direct relevance to understanding certain disorders of human reproduction, including idiopathic hypogonadotropic hypogonadism, androgen insensitivity syndrome, meiotic arrest, Sertoli cell only syndrome, and oligospermia or azoospermia. Our clinical project is focused on understanding the functional significance of the hormonal and genetic environment required for spermatogenesis in men. The basic science projects investigate the neuroendocrine control of gonadotropin secretion, the molecular basis of the blood-testis barrier, and the key signaling pathways that regulate the development and function of mature gametes. Each project involves a collaboration with at least one other in the Center, and the molecular physiology is integrated with the clinical investigation. We believe this approach will offer the best opportunity to provide the scientific rationale for the development of improved therapies to treat certain disorders of reproduction and serve as the basis for the development of better options for hormonal contraception in men. We are committed to scientific excellence and communication across disciplines, ranging from molecular biology to physiology and medicine. Our proposal incorporates the talents of outstanding investigators, whose experience and knowledge represent a rich and broad perspective on reproductive biology and its relevance to human health. We have deliberately structured the Center to bring together the best and most accomplished reproductive biologists and physician-scientists at the University of Washington in a scientific collaboration. We look forward to our continued participation in the NIH Specialized Cooperative Centers Program in Reproductive Research (SCCPRR). We share its goal of fostering communication, innovation and research excellence, with the ultimate goal of improving human reproductive health through accelerated transfer of discoveries made at the bench into clinical practice. We are committed to the collaborative spirit of the SCCPRR and have established collaborations with investigators at SCCPRR Programs at several other institutions. We look forward to contributing to the outstanding clinical and basic research in this important national program.