New England Regional Center of Excellence in Biodefense and Emerging Infectious D

项目总结（见说明）： 新英格兰地区卓越中心。Kasper，医学博士 新英格兰地区生物防御和新发传染病研究卓越中心（MERGE）已成为生物防御和新发传染病研究和开发的焦点，开发了治疗和预防感染的新方法。NERCE一直支持其核心实验室，并被来自新英格兰和全国各地的学术界、公共卫生部门以及生物制药和生物技术行业的科学家所利用。中心 作为基础、转化和临床研究科学家的催化剂，开展研究，开发针对传染病的新产品。 NERCE将继续这一使命，支持研究解决三个主要主题-"高致病性RNA病毒"，"细菌毒素和其他致病蛋白质"，和"革兰氏阴性细菌-发病机制和免疫"。该中心将继续强调“化学生物学”和高通量的实验发现方法。NERCE还将支持五个核心实验室- "微生物学和动物资源"、"生物分子生产"、"小分子筛选"、"靶标鉴定"和"分子成像"。这些核心资源可供整个新英格兰使用 传染病社区致力于NIAID优先病原体和新出现的传染病病原体 疾病小分子筛选核心（国家筛选实验室的研究中心， 卓越的生物防御和新兴传染病研究，或NSRB）支持科学家 隶属于十个区域中心中的任何一个。 NERCE还将继续其发展项目计划和生物防御职业发展 该计划旨在启动新的研究工作，并吸引新的研究人员进入这一领域。

PROJECT SUMMARY (See instructions): NEW ENGLAND REGIONAL CENTER OF EXCELLENCE, Dennis L. Kasper, M.D. The New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (MERGE) has become a focal point for research and development in biodefense and emerging infectious diseases, developing novel approaches to treatment and prevention of infections. NERCE has supported and its core labs have been utilized by scientists from academia, the public health sector and the biopharmaceutical and biotechnology industries based in New England and across the country. The center functions as a catalyst for basic, translational and clinical research scientists to conduct research leading to new products directed against infectious disease. NERCE will continue this mission by supporting research addressing three primary themes - "Highly Pathogenic RNA Viruses", "Bacterial Toxins and other Pathogenic Proteins", and "Gram-Negative Bacteria -Pathogenesis and Immunity". The Center will continue its emphasis on "Chemical Biology" and high throughput approaches to experimental discovery. NERCE will also be supporting five core labs - "Microbiology and Animal Resources", "Biomolecule Production", "Small Molecule Screening", "Target Identification", and "Molecular Imaging". These core resources are available to the entire New England infectious disease community working on NIAID priority pathogens and agents of emerging infectious disease. The small molecule screening core (National Screening Laboratory for the Research Centers of Excellence in Biodefense and Emerging Infectious Diseases Research, or NSRB) supports scientists affiliated with any of the ten Regional Centers. NERCE will also continue its Developmental Projects program and Career Development in Biodefense program in an effort to initiate new research efforts and to attract new investigators to this field.