New England Regional Center of Excellence in Biodefense and Emerging Infectious D

描述（由申请人提供）：新英格兰生物防御和新发传染病研究卓越区域中心（NERCE）已成为生物防御和新发传染病研究和开发的焦点，开发治疗和预防感染的新方法。新英格兰和全国各地的学术界、公共卫生部门以及生物制药和生物技术行业的科学家支持并利用了该中心的核心实验室。该中心的作用是促进基础研究、转化研究和临床研究科学家开展研究，开发针对传染病的新产品。该中心将继续开展这项任务，支持研究三个主要主题：“高致病性RNA病毒”、“细菌毒素和其他致病性蛋白质”和“革兰氏阴性菌——发病机制和免疫”。该中心将继续强调“化学生物学”和实验发现的高通量方法。该中心还将支持五个核心实验室——“微生物与动物资源”、“生物分子生产”、“小分子筛选”、“靶标鉴定”和“分子成像”。这些核心资源可供整个新英格兰传染病社区使用，他们致力于研究NIAID的重点病原体和新发传染病的病原体。小分子筛选核心（生物防御和新发传染病研究卓越研究中心国家筛选实验室，简称NSRB）支持隶属于十个区域中心中的任何一个的科学家。NERCE还将继续其发展项目计划和生物防御计划的职业发展，以努力启动新的研究工作并吸引新的研究人员进入该领域。

DESCRIPTION (provided by applicant): The New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (NERCE) has become a focal point for research and development in biodefense and emerging infectious diseases, developing novel approaches to treatment and prevention of infections. NERCE has supported and its core labs have been utilized by scientists from academia, the public health sector and the biopharmaceutical and biotechnology industries based in New England and across the country. The center functions as a catalyst for basic, translational and clinical research scientists to conduct research leading to new products directed against infectious disease. NERCE will continue this mission by supporting research addressing three primary themes - "Highly Pathogenic RNA Viruses", "Bacterial Toxins and other Pathogenic Proteins", and "Gram-Negative Bacteria - Pathogenesis and Immunity". The Center will continue its emphasis on "Chemical Biology" and high throughput approaches to experimental discovery. NERCE will also be supporting five core labs - "Microbiology and Animal Resources", "Biomolecule Production", "Small Molecule Screening", "Target Identification", and "Molecular Imaging". These core resources are available to the entire New England infectious disease community working on NIAID priority pathogens and agents of emerging infectious disease. The small molecule screening core (National Screening Laboratory for the Research Centers of Excellence in Biodefense and Emerging Infectious Diseases Research, or NSRB) supports scientists affiliated with any of the ten Regional Centers. NERCE will also continue its Developmental Projects program and Career Development in Biodefense program in an effort to initiate new research efforts and to attract new investigators to this field. RELEVANCE: The programs supported through the New England RCE will provide the basic knowledge necessary for development of therapeutics, vaccines, and diagnostics directed against biodefense and emerging infectious disease pathogens. These programs will also provide training opportunities for investigators entering and active in the field. STRATEGIC MANAGEMENT PLAN and ADMINISTRATION CORE: Strategic Plan and Management (Core Leader, D. Kasper)