MMC and VICC: Partnership for Survivorship (1 of 2)

梅哈里医学院(MMC)和范德比尔特-英格拉姆癌症中心(VICC)提议开发一项以癌症生存研究和癌症生存健康差异为中心的新的创新计划。这是一个可持续和互惠互利的计划，显著加强了目前由梅哈里-范德比尔特癌症伙伴关系(MVCP)资助的U54，并有效地利用了已经建立的资源。目前，美国有1100多万人患有癌症，其中非洲裔美国人的死亡率高于其他种族/族裔群体，其原因尚不完全清楚。对于癌症幸存者来说，癌症治疗、生活方式和环境暴露的影响也会导致长期发病率和过早死亡。然而，令人惊讶的是，在“生存”方面进行的研究很少，以评估长期结果，特别是在成年癌症幸存者中，特别是在存在基线健康差距的少数群体幸存者中。因此，需要进行描述性和分析性流行病学队列研究，以估计不良生理和心理社会长期后果的发生率，并评估其决定因素，以便为制定预防干预的最佳做法提供信息。这项建议旨在计划、优先和实施一系列合作试点项目，使用混合方法，具体目标如下：1)将癌症生存研究倡议作为MVCP的优先事项，并将这一研究和临床护理领域整合到现有的伙伴关系基础设施中；2)促进MMC、VICC和一个合作的少数族裔机构田纳西州立大学教职员工之间的互动和合作；3)促进对癌症生存中健康差异的决定因素的研究，包括与服务不足的人群(包括有社会经济挑战的有色人种)较差生存相关的生物、社会经济、人口和健康相关风险因素；以及4)确定癌症治疗后与健康相关的不良后果的发生率、患病率、谱系和严重程度，并制定干预措施以预防或改善此类后果。这种扩大的伙伴关系和研究计划对MMC和VICC都有好处：1)教师发展和招聘，学员和初级教师更多地接触这一研究领域；2)试点项目和最终具有竞争力的外部资金增加，现在将包括整个癌症控制连续体的研究；3)扩大MVCP资助的U54和VICC支持赠款，将癌症生存研究包括在内；4)扩大癌症健康差异研究，将长期生存质量和数量的差异研究包括在内；5)促进研究人员和受试者更多地参与癌症生存差异研究。

The Meharry Medical College (MMC) and the Vanderbilt-lngram Cancer Center (VICC) propose to develop a new and innovative program centered on Cancer Survivorship Research and Cancer Survivorship Health Disparities. This is designed to be a sustainable and mutually beneficial program that significantly enhances the current Meharry-Vanderbilt Cancer Partnership (MVCP) funded U54, and efficiently utilizes already established resources. There are now over 11 million people in the United States living with a history of cancer with African Americans experiencing higher rates of mortality than do other racial/ethnic groups for reasons that are only partly understood. For cancer survivors, effects of the cancer treatment, lifestyle behaviors and environmental exposures can also lead to long-term morbidity and premature mortality. Yet, surprisingly little research has been conducted in "survivorship" to assess long term outcomes especially among adult cancer survivors, and in particular, minority survivor populations where baseline health disparities exist. Therefore, descriptive and analytic epidemiologic cohort studies are required to estimate the incidence of adverse physiologic and psychosocial long-term outcomes and evaluate their determinants to inform the development of best practices for preventive interventions. This proposal is designed to plan, prioritize and implement a series of collaborative pilot projects, using mixed methodologies with the following specific objectives: 1) To establish Cancer Survivorship research initiatives as a priority for the MVCP and integrate this area of research and clinical care into the existing partnership infrastructure; 2) To stimulate interactions and collaborations among faculty at MMC, VICC and a collaborating minority institution, Tennessee State University; 3) To stimulate research into the determinants of health disparities in cancer survivorship, including the biologic, socioeconomic, demographic and health-related risk factors associated with inferior survival of underserved populations (including populations of color, socio-economically challenged); and 4) To identify the incidence, prevalence, spectrum, and severity of adverse long-term health-related outcomes following cancer treatment and develop interventions to prevent or ameliorate such outcomes. The benefits of such an expanded partnership and program of research include for both MMC and VICC: 1) faculty development and recruitment with increased exposure to this line of research for trainees and junior faculty; 2) increases in pilot projects and ultimately competitive extramural funding that will now include research along the entire cancer control continuum; 3) expansion of the MVCP funded U54 and VICC support grant to include cancer survivorship research; 4) expansion of cancer health disparities research to include study of disparities in the quality and quantity of long-term survivorship; 5) facilitation of increased minority participation in cancer survivorship disparities research, with respect to both investigators and subjects.