Aspergillus Genome Database

描述（由申请人提供）：该项目的目标是基于用于酵母菌和念珠菌基因组数据库的软件和模式，为曲霉菌开发一个数据库，其中将有与特定基因相关的文献数据。在整理文献时，我们将记录基因名称和别名、基因本体注释和突变表型，并为探索基因组及其注释提供工具和接口。此外，我们将进一步开发和完善一个强大的、最先进的基因组注释管道，并使用它对每个曲霉进行初级基因组注释。该管道将利用曲霉菌之间的比较基因组数据，并将定期重新运行，或者当新数据出现时（例如额外的基因组），或者当改进的算法被纳入管道时。因此，我们将为曲霉菌研究界提供高质量的文献管理，以及每个基因组的最佳初步注释。通过这种方式，正如在其他生物研究界所做的那样，我们将帮助加快对曲霉的研究，使研究人员能够轻松访问相关的注释信息。这一点尤其重要，因为曲霉既含有机会致病菌烟熏假单胞菌，也含有模式遗传生物假单胞菌，对这些生物的研究将对人类健康产生积极影响。公共卫生相关性：烟曲霉是一种遍布世界各地的机会性病原体，主要感染嗜中性粒细胞减少的动物宿主；它是人类侵入性霉菌感染的最常见原因，也是显著发病率和死亡率的原因。烟曲霉引起的侵袭性疾病在没有抗真菌药物治疗的情况下死亡率很高；即使得到治疗，死亡率仍至少为50%。该项目的成功完成，将提供一个精心整理的曲霉数据库，可能会加速曲霉的研究，这样做将有助于对抗烟曲霉感染，从而对人类健康产生重大积极影响。

DESCRIPTION (provided by applicant): The goal of this project is to develop a database, based on the software and schema used for the Saccharomyces and Candida Genome Databases, for the Aspergilli, wherein there will be data curated from the literature connected to specific genes. In curating the literature, we will record gene names and aliases, Gene Ontology annotations, and mutant phenotypes, as well as provide tools and interfaces for exploring the genome and its annotations. In addition, we will further develop and refine a robust, state-of-the-art genome annotation pipeline, and use this to perform primary genome annotation on each of the Aspergilli. This pipeline will take advantage of comparative genomic data between the Aspergilli, and will be re-run periodically, either when new data come to light (such as additional genomes), or when improved algorithms are incorporated into the pipeline. Thus, we will provide to the Aspergillus research community high quality literature based curation, coupled with the best possible primary annotation of each of the genomes. In this way, as has been done in other organism research communities, we will help to accelerate research into the Aspergilli, by enabling researchers to easily access relevant annotation information. This is particularly important, as the Aspergilli contain both the opportunistic pathogen, A. fumigaus, as well as the model genetic organism, A. nidulans, and enabling research into these organism will have a positive impact on human health. PUBLIC HEALTH RELEVANCE: Aspergillus fumigatus is an opportunistic pathogen found throughout the world and primarily infects neutropenic animal hosts; it is the most common cause of invasive mold infections in humans and the cause of significant morbidity and mortality. Invasive disease caused by A. fumigatus has a high mortality rate in the absence of antifungal drug therapy; even with treatment, mortality still remains at least 50%. Successful completion of this project, to provide a curated Aspergillus database, will likely accelerate Aspergillus research, and in doing so will aid in the fight against A. fumigatus infections, and thus significantly positively impact human health.