Administration

塔夫茨大学医学院圣伊丽莎白医学中心癌症系统生物学中心 (TUSM)，汇集了来自生物、数学、物理和临床的不同研究人员 背景：更好地了解癌症发生和发展的分子和功能水平事件 发展。CCSB成立三年来，已经成熟为一个久负盛名、深入人心的 互动和多学科癌症小组，它正在成为一个具有国际竞争力的研究 以及在癌症系统生物学方面的培训设施和研究数据库塔夫茨CCSB已经 两项由联邦政府资助的多学科致癌项目资助项目的获得者。每个人 将数学和计算机建模与最先进的实验癌症生物学相结合。这个 第一个是美国国家航空航天局专门研究中心(NSCOR)资助的实体肿瘤致癌风险研究 来自太空辐射照射(1000万美元；PI博士)。第二个是美国能源部资助的研究中心 背景辐射的低剂量辐射暴露后的致癌风险(750万美元给Dr。 HIatky和100万美元给了HahnFeldt博士，用于对这个问题的数学分析)。显然，私家侦探和 该中心精通于运营致癌方面的大型项目拨款。为ICBP申请提供资金 将提供一个机会，将这个已建立的CCSB与ICBP资助的国家网络连接起来 全国各地的中心也开始预测五种癌症模型，从而为NCI做出贡献 本计划的指导目标。尼古拉斯·马迪亚斯医学博士，医学主任，SEMC，TUSM故意 建立CCSB的战略决策，聘请HIatky博士担任主任，以及致力于 实验室研究空间和计算资源，以及随后她的团队的扩大， 代表着一项重大的不适当的投资，并限制了对创新的承诺，遏制了边缘癌症 研究。SEMC通过一项大规模的扩张计划来支持这一研究承诺 在肿瘤学中心实施其临床服务，涉及Rad One额外的8,000平方英尺 和一个额外的8,000平方英尺的内科肿瘤学(见支持信马迪亚斯博士)。广度和深度 SEMC对这一长期战略目标的承诺是明确的。它的约束强度 研究人员和临床培训加强了智力、学术和培训环境 通过TUSM预约。

The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and fissue-level events underlying cancer evolufion and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and mulfidisciplinary cancer group which it is becoming an internafionally competifive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathemafical and computafional modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million; PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP applicafion would provide an opportunity to connect this established CCSB with the nafional networks of ICBP-funded Centers around the country also embarking on predicfive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruifing Dr. HIatky as director, and the dedicafion of laboratory research space and compufing resources, as well as the subsequent expansion of her group, represents a major insfitufional investment and confinuing commitment to innovafive, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an addifional 8,000 sq ft for Rad One and an addifional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The confinuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.