DO ORAL CONTRACEPTIVES CAUSE WEIGHT GAIN?

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这笔赠款探索了口服避孕药对成年后体重控制的影响。许多女性停止服用口服避孕药，因为她们担心会有副作用，体重增加。但这种未能持续服用口服避孕药的做法会导致意外怀孕率的增加。令人惊讶的是，对动物(小鼠、大鼠、猫、狗、猴子)的研究表明，去卵巢的动物服用雌激素和黄体酮通常会导致体重减轻，而不是体重增加。这笔赠款的总体目标是记录卵巢完整的灵长类动物在一年内长期服用口服避孕药(OC)时体重的变化。我们假设，服用口服避孕药一年的猴子实际上可能会经历轻微的体重减轻；这一发现将使人们认为口服避孕药在导致体重增加方面的副作用不可信。所有猴子都完成了研究方案，没有任何不良反应。与基线相比，服用避孕药后代谢率显著增加，体重减轻，体脂百分比降低。当分别分析这些组(肥胖和正常)时，肥胖组对整个组的显著变化负有责任。在整个组和基于体重指数的两组中，食物摄入量、活动量水平或使用OC的瘦肉量百分比没有变化。总体而言，OC的使用似乎增加了雌性猴子的24小时代谢率，这反过来似乎对体重和体脂百分比的影响不同，这取决于基线体重。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant explores the effect of oral contraceptives on body weight control in adulthood. Many women stop taking oral contraceptives because they are concerned about a perceived side effect, weight gain. But this failure to consistently take oral contraceptives leads to increased rates of unintended pregnancy. Surprisingly, studies in animals (mice, rats, cats, dogs, monkeys) have shown that estrogen and progesterone administration to ovariectomized animals generally leads to weight loss, rather than weight gain. The overall goal of this grant is to document changes in body weight when ovary-intact primates are chronically given oral contraceptives(OC) for a one-year period of time. We hypothesized that monkeys taking oral contraceptives for a yearmay in fact experience a mild weight loss; a finding which would discredit the perceived side effect of oral contraceptives in causing weight gain. All monkeys completed the study protocol with no adverse events. A significant increase in metabolic rate, a decrease in body weight, and a decrease in % body fat with pill use was found as compared to baseline. When analyzing the groups separately (obese versus normal), the obese group was responsible for the significant changes seen for the entire group.. No changes were seen in food intake, activity level, or % lean muscle mass with OC use for the entire group and for either BMI-based group. Overall, OC use appears to increase 24 hour metabolic rate in female monkeys, which in turn appears to differentially affect weight and % body fat depending on baseline weight.