CENTRAL SYMPATHETIC REGULATION OF THERMOGENESIS IN FEVER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 了解调节发热和感冒防御的中枢神经机制将有助于开发治疗方法来对抗危及生命的过度发热（如在脓毒症、毒血症、脑膜炎、某些癌症期间）以及在诸如滥用安非他明类药物的临床显著病症期间发生的热失调的影响的管理，更年期和前列腺手术引起的潮热或手术麻醉引起的体温过低。本项目的目的是阐明调节体温的中枢神经系统回路以及它们如何受到热原的影响。 最近的研究结果包括确定从视前区的发热抑制神经元到背内侧下丘脑的BAT交感兴奋区和中缝苍白肌的不同投射，证明下丘脑室旁核神经元激活的主要作用是抑制BAT产热，并阐明脊髓5-羟色胺释放在冷却过程中的突出去抑制作用，引起BAT产热和能量消耗的增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding of the central neural mechanisms mediating fever and cold defense will be relevant for developing therapeutic approaches to combat life-threatening excessive fevers (as during sepsis, toxemia, meningitis, some cancers) and to the management of the effects of thermal dysregulation that occurs during such clinically significant conditions as the abuse of amphetamine-based drugs, the hot flashes accompanying menopause and prostate surgery or the hypothermia induced during surgical anesthesia. The aims of this project are to elucidate the CNS circuits that regulate body temperature and how they are affected by pyrogens. Recent findings include the identification of distinct projections from the fever-inhibited neurons in the preoptic area to the BAT sympathoexcitatory regions of the dorsomedial hypothalamus and to the raphe pallidus, the demonstration that the principal effect of neuronal activation in the paraventricular hypothalamic nucleus is an inhibition of BAT thermogenesis and the elucidation of a prominent disinhibitory role for spinal serotonin release in the cooling-evoked increase in BAT thermogenesis and energy expenditure.