IMAGING MEDIAL TEMPORAL LOBE ACTIVITY - MEMORY & EMOTION IN AWAKE MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 内侧颞叶在情绪和记忆中的作用已经在动物和人类中进行了广泛的侵入性研究，使用神经成像技术。然而，如果能够应用类似的技术来验证与行为相关的神经活动，人类和动物研究之间的联系将得到加强。我们建议使用功能磁共振成像来研究海马体和杏仁核在清醒的、行为正常的恒河猴情绪和记忆中的作用。我们目前已经建造了灵长类座椅，可以在神经成像测试期间固定清醒的猴子；编写软件，允许在扫描仪脉冲触发的扫描仪中呈现视觉刺激；使受试者适应扫描仪和眼睛跟踪器；并进行最初的一系列扫描，以验证我们的扫描参数。这些数据目前正在分析中，因此我们可以在最终扫描之前调整任何剩余的参数。这些初步实验将在耶克斯建立这项技术，并使未来的研究能够选择性地操纵大脑结构，探索行为和神经活动的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The medial temporal lobe's role in emotion and memory has been extensively studied invasively in animals, and in humans using neuroimaging. However, the link between human and animal studies would be strengthened if similar techniques can be applied to verify the neural activity associated with behavior. We proposed to use functional MRI to study the roles of the hippocampus and amygdala in emotion and memory in awake, behaving rhesus macaques. We have currently built the primate chair that will permit to immobilize the awake monkeys during neuroimaging testing; written the software to permit presentation of visual stimuli in the scanner triggered by the scanner pulse; acclimated subjects to the scanner and eye-tracker ; and conducted the initial series of scans to validate our scanning parameters. Those data are currently being analyzed so we can adjust any remaining parameters prior to final scanning. These initial experiments will establish the technique at Yerkes and enable future studies that will selectively manipulate brain structures and explore changes in behavior and neural activity.