Trauma-Focused CBT: Potential Mechanisms that Inhibit and Facilitate Change

描述（由申请人提供）：儿童虐待和人际关系逆境使儿童患创伤后应激障碍（PTSD）、抑郁症和自杀、药物滥用以及一系列负面心理健康结果的风险增加。最近的证据表明，童年的逆境可能会产生有害的神经生物学和心理社会影响，将风险延伸到成年。以创伤为中心的认知行为疗法（TF-CBT）已在许多随机临床试验中被证明是一种有效的治疗虐待和创伤儿童。TF-CBT的早期干预有可能改变与儿童逆境相关的风险轨迹。拟议研究的总体目标是确定潜在的变化机制，变化的抑制剂，以及这种治疗中早期脱落的预测因素。拟议的研究将对变化过程的复杂分析整合到正在进行的TF-CBT有效性试验中，该试验已被运送到整个特拉华州的社区精神卫生设施。来自75名接受TF- CBT的儿童的会议将使用观察编码系统进行编码，该系统旨在捕获理论上重要的治疗过程。TF-CBT被假设为与会话中情感唤醒和创伤的认知/情感处理的曲线模式相关，当儿童在治疗的暴露阶段形成创伤叙述时，峰值水平出现。情感唤醒的短暂增加被认为反映了创伤记忆的激活并促进了处理。在这个叙述阶段更多的处理被假设为PTSD症状和问题儿童行为改善的主要预测因素。治疗师的支持和照顾者参与治疗，预计将有助于减少回避，后来的唤醒和处理的主要抑制剂的孩子准备的变化。照顾者的回避和处理时，暴露于儿童的叙述也预计预测儿童的结果。拟议的研究有可能揭示关键过程，可以动员，以提高TF-CBT的效力，降低辍学率，并加强治疗师培训的传播工作进行。 公共卫生相关性：儿童虐待和人际创伤增加了许多严重精神健康障碍的风险。童年的逆境可能与有害的神经生物学和心理社会后遗症有关，这些后遗症将风险延伸到成年期。以创伤为中心的认知行为疗法（TF-CBT）是一种有创伤支持的治疗方法，可以改变这种可识别的风险轨迹。拟议研究的目标是确定抑制和促进治疗变化的关键过程。了解TF-CBT如何产生即时和长期效果可以指导提高其效力、减少脱落和优化治疗交付的努力。

DESCRIPTION (provided by applicant): Child maltreatment and interpersonal adversity put children at increased risk for posttraumatic stress disorder (PTSD), depression and suicide, substance abuse, and a host of negative mental health outcomes. Recent evidence documents that childhood adversity can have pernicious neurobiological and psychosocial effects that extend risk into adulthood. Trauma- Focused Cognitive-Behavioral Therapy (TF-CBT) has been demonstrated in numerous randomized clinical trials to be an efficacious treatment for maltreated and traumatized children. Early intervention with TF-CBT has the potential to alter the trajectory of risk associated with childhood adversity. The overall goals of the proposed research are to identify potential mechanisms of change, inhibitors of change, and predictors of early dropout in this treatment. The proposed research integrates a sophisticated analysis of the process of change into an ongoing effectiveness trial of TF-CBT that has been transported to community mental health facilities throughout the state of Delaware. Sessions from 75 children who received TF- CBT will be coded with an observational coding system designed to capture theoretically important therapeutic processes. TF-CBT is hypothesized to be associated with a curvilinear pattern of in-session affective arousal and cognitive/emotional processing of the trauma, with peak levels occurring when the child develops a trauma narrative in the exposure phase of therapy. A transient increase in affective arousal is thought to reflect activation of the trauma memories and to facilitate processing. More processing during this narrative phase is hypothesized to be the primary predictor of improvement in PTSD symptoms and problematic child behaviors. Therapist support and caregiver involvement in treatment are expected to help prepare the child for change by decreasing avoidance, a primary inhibitor of later arousal and processing. Caregiver avoidance and processing when exposed to the child's narrative are also expected to predict child outcomes. The proposed research has the potential to reveal key processes that can be mobilized to increase the potency of TF-CBT, reduce rates of dropout, and enhance therapist training as dissemination efforts are undertaken. PUBLIC HEALTH RELEVANCE: Child maltreatment and interpersonal trauma increase risk for a number of serious mental health disorders. Childhood adversity can be associated with pernicious neurobiological and psychosocial sequelae that extend risk into adulthood. Trauma- Focused Cognitive-Behavioral Therapy (TF-CBT) is an empirically-supported treatment that can alter this identifiable trajectory of risk. The goal of the proposed research is to identify key processes that inhibit and facilitate therapeutic change. Understanding how TF-CBT has its immediate and long-term effects can guide efforts to increase its potency, reduce dropout, and optimize therapy delivery.