Project 7

这项申请需要五年的支持，以便在加州大学洛杉矶分校建立一个多学科研究中心 题为“加强认知控制的翻译研究”，作为NIMH中心的一部分 干预发展和应用研究(CIDAR)计划。利用我们在动物模型方面的专业知识， 认知神经科学，神经成像，神经精神药理学，行为疗法，遗传学，我们将 推进治疗认知缺陷的科学方法，这些缺陷是大量 折磨儿童和青少年的神经精神障碍。我们将特别关注儿科疾病 认知控制的突出问题，特别是经常重叠的注意力障碍- 缺陷/多动障碍(ADHD)和抽动症(TS)，由于其治疗需求未得到满足， 患病率、发病率和合并症，以及共同的病理生理特征。最终，我们相信我们的 工作将与更多患有其他疾病但具有相同维度的儿童相关 在行为规范、认知处理和判断方面存在严重缺陷。 加州大学洛杉矶分校CIDAR TRECC中心的中心主题是对 一系列发展性精神病共同的认知缺陷潜在机制 导致开发和测试有针对性的更有效的治疗方法，以增强 在这些条件下的认知。我们的重点是直接响应巴勒斯坦权力机构的号召，发展 明确影响发病率但不影响发病率的疾病临床靶点的治疗方法 通过现有的治疗方法得到了充分的补救。发展性精神病中明显的认知障碍 作为运作和长期结果的主要决定因素。我们非常需要认识到 将认知增强作为儿科疾病的主要治疗目标，并开发和测试新的 治疗方法正在接近。如果成功，这些努力有望显著改善长期 这些残障人士的结果。加州大学洛杉矶分校CIDAR中心将通过 利用已开发的资源，完成四项动物和人类相互作用的多层次研究 并通过CIDAR中心支持的三个研究中心提供。

This application requests five years of support to establish a multidisciplinary research center at UCLA entitled "Translational Research to Enhance Cognitive Control (TRECC)" as a part of the NIMH Centers for Intervention Development and Applied Research (CIDAR) program. Utilizing our expertise in animal models, cognitive neuroscience, neuroimaging, neuropsychopharmacology, behavioral therapies, genetics, we will advance the science of treatment approaches for the cognitive deficits common to a large number of neuropsychiatric disorders afflicting children and adolescents. We will especially focus on pediatric disorders with prominent problems of cognitive control, particularly the often overlapping disorders of Attention- Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS), due to their unmet treatment needs, prevalence, morbidity and comorbidity, and shared pathophysiologic features. Ultimately, we believe our work will be relevant to an even larger group of children with other conditions, but who share the dimension of significant deficits in behavior regulation, cognitive processing, and judgement. The central theme of the UCLA CIDAR TRECC Center is the understanding and modeling of the mechanisms underlying cognitive deficits shared by a range of developmental psychopathologies leading to the development and testing of targeted and more efficacious treatments to enhance cognition in these conditions. Our focus is in direct response to the PA's call for the development of treatment approaches for clinical targets of illnesses which clearly influence morbidity but which are not sufficiently remediated by extant treatments. Impaired cognition in developmental psychopathologies clearly serves as a major determinant of functioning and long-term outcome. There is a great need to recognize cognitive enhancement in pediatric disorders as a primary treatment target and to develop and test new treatment approaches. If successful, such efforts hold the promise of significantly improving the long-term outcome of individuals with these disabilities. The UCLA CIDAR Center will approach this theme through the completion of four interacting multi-level studies in animals and humans, utilizing the resources developed and made available through three research cores supported by the CIDAR Center.