Imaging Core

这个核心的目的是为赠款中的项目提供基础设施资源，利用Magic 磁共振成像，并开发可供当前项目和未来共享的资源 与额叶纹状体环路发育障碍相关的项目。它将包括四个主要组成部分 成像核心：技术分核，专注于测试和确保高图像质量和 整合新的技术发展，包括新的脉冲序列，并行成像 技术、头部梯度集、快速重建算法、同步EEG/fMRI以及 支持结构磁共振成像和弥散张量成像。设计和分析子核心将提供以下专业知识 设计和实施功能磁共振实验，并分析功能磁共振、结构磁共振和DTI数据，以及 分析。行为训练/脱敏单元将使用具有生物反馈的模拟MRI环境来 使儿科受试者对环境和跟踪头部运动脱敏的可能性最大化 成功扫描困难人群。最后，一个分析和数据库股将进行功能磁共振成像 对CIDAR项目进行分析，并管理和维护结构磁共振数据库。结构和DTI数据 在成像核心中获得的将提供给所有人类项目(1，3和4)，以测试特定的假设 前纹状体回路的结构和功能连接。提供的基础设施资源 成像核心是项目3和4不可或缺的组成部分，并使进入项目1的对象受益；这些资源将 可用于未来几年可能访问加州大学洛杉矶分校CIDAR的未来儿科成像研究。一种成像 致力于促进ADHD和Tourette‘s神经生物学研究的核心将使我们能够解决 儿科影像中的一些比较困难的问题，即图像采集的技术困难 在眼眶-额叶视网膜；对发育中的大脑进行分析，可能包含结构差异或 异常；儿童大脑发育的变异性；以及扫描儿童脑部疾病的实际困难 认知控制障碍。在成像研究的每个阶段都拥有核心资源，从设计到 通过数据分析获取图像，将使不是成像专家的调查人员能够应用这些 方法用于其他发育障碍，并将提供资源来评估新的 行为和药物治疗对发育障碍患者大脑功能的影响。

The purpose of this core is to provide infrastructure resources for projects in the grant utilizing Magnetic Resonance Imaging, and to develop resources that may be shared for the current projects as well as future projects relevant to developmental disorders in fronto-striatal circuits. There will be four primary components of the Imaging Core: a technical sub-core, focused on testing and ensuring high image quality and integrating new technological developments developments including novel pulse sequences, parallel imaging technology, a head gradient set, rapid reconstruction algorithms, and simultaneous EEG/fMRI,as well as supporting structural MRi and DTI acqiuisition. A design and analysis sub-core will provide expertise for designing and implementing fMRi experiments, and analysis of fMRI, structural MRI and DTI data, and analysis. A behavioral training/desensitization unit will use a simulated MRi environment with biofeedback to desensitization pediatric subjects to the environment and track head motion to maximize the likelihood of successfully scanning difficult populations. Finally, an analysis and databasing unit will conduct fMRI analyses for CIDAR projects and manage and maintain a structural MRI database. Structural and DTI data acquired in the Imaging core will feed into all of the human projects (1,3,and 4) to test specific hypothesis of structural and functional connectivity in front-striatal circuits. The infrastructure resources provided by the Imaging Core is integral to projects 3 and 4 and benefits subjects entering Project 1; these resources will be available for future pediatric imaging studies that may access the UCLA CIDAR in future years. An imaging core dedicated to promoting research into the neurobiology of ADHD and Tourette's will enable us to tackle some of the more difficult problems in pediatric imaging, namely, the technical difficulties in image acquisition in orbito-frontal retgions; analysis of developing brains that may contain structural differences or abnormalities; variability in brain development in children; and practical difficulties in scanning children with disorders of cognitive control. Having core resources at every stage of the imaging study, from design and image acquisition through data analysis, will enable investigators who are not imaging experts to apply these methods to other developmental disorders, and will provide resources to evaluate the effects of new treatments, both behavioral and pharmacological, on brain function in developmental disorders.