Imaging Core

成像核心

• 批准号: 8136575
• 负责人: JAMES T. MCCRACKEN
• 金额: $ 14.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-31 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136575
• 关键词: Algorithms; Architecture; Area; Attention deficit hyperactivity disorder; Behavior Disorders; Behavioral; Biofeedback; Brain; Brain imaging; Child; Childhood; Computer software; Consult; Consultations; Corpus striatum structure; Data; Data Analyses; Data Quality; Databases; Development; Disease; Education; Electronics; Ensure; Environment; Experimental Designs; Feedback; Freedom; Functional Magnetic Resonance Imaging; Future; Gilles de la Tourette syndrome; Goals; Grant; Head; Human; Human Resources; Image; Image Analysis; Imaging technology; Individual; Laboratories; Magnetic Resonance Imaging; Magnetism; Methodology; Methods; Morphologic artifacts; Motion; Neurobiology; Physiologic pulse; Population; Predisposition; Protocols documentation; Quality Control; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Scanning; Services; Signal Transduction; Simulate; Solutions; Staging; System; Techniques; Testing; Training; Training Programs; Variant; base; cognitive control; data mining; desensitization; design; developmental disease; experience; feeding; image processing; improved; novel; programs; reconstruction; research study; simulation; software development; tool; user-friendly

The purpose of this core is to provide infrastructure resources for projects in the grant utilizing Magnetic Resonance Imaging, and to develop resources that may be shared for the current projects as well as future projects relevant to developmental disorders in fronto-striatal circuits. There will be four primary components of the Imaging Core: a technical sub-core, focused on testing and ensuring high image quality and integrating new technological developments developments including novel pulse sequences, parallel imaging technology, a head gradient set, rapid reconstruction algorithms, and simultaneous EEG/fMRI,as well as supporting structural MRi and DTI acqiuisition. A design and analysis sub-core will provide expertise for designing and implementing fMRi experiments, and analysis of fMRI, structural MRI and DTI data, and analysis. A behavioral training/desensitization unit will use a simulated MRi environment with biofeedback to desensitization pediatric subjects to the environment and track head motion to maximize the likelihood of successfully scanning difficult populations. Finally, an analysis and databasing unit will conduct fMRI analyses for CIDAR projects and manage and maintain a structural MRI database. Structural and DTI data acquired in the Imaging core will feed into all of the human projects (1,3,and 4) to test specific hypothesis of structural and functional connectivity in front-striatal circuits. The infrastructure resources provided by the Imaging Core is integral to projects 3 and 4 and benefits subjects entering Project 1; these resources will be available for future pediatric imaging studies that may access the UCLA CIDAR in future years. An imaging core dedicated to promoting research into the neurobiology of ADHD and Tourette's will enable us to tackle some of the more difficult problems in pediatric imaging, namely, the technical difficulties in image acquisition in orbito-frontal retgions; analysis of developing brains that may contain structural differences or abnormalities; variability in brain development in children; and practical difficulties in scanning children with disorders of cognitive control. Having core resources at every stage of the imaging study, from design and image acquisition through data analysis, will enable investigators who are not imaging experts to apply these methods to other developmental disorders, and will provide resources to evaluate the effects of new treatments, both behavioral and pharmacological, on brain function in developmental disorders.

这个核心的目的是提供基础设施资源的项目在赠款利用磁性 共振成像，并开发可用于当前项目和未来项目的资源 与额-纹状体回路发育障碍相关的项目。将有四个主要组成部分 成像核心：技术子核心，专注于测试和确保高图像质量， 整合新的技术发展，包括新的脉冲序列，并行成像， 技术，头部梯度设置，快速重建算法，和同步EEG/fMRI，以及 支持结构MRI和DTI采集。一个设计和分析分核心将为以下方面提供专门知识： 设计和实施fMRI实验，分析fMRI、结构MRI和DTI数据， 分析.行为训练/脱敏单元将使用具有生物反馈的模拟MRI环境， 使儿科受试者对环境脱敏，并跟踪头部运动，以最大限度地提高 成功扫描困难人群。最后，一个分析和数据库单元将进行功能磁共振成像， CIDAR项目的分析和管理和维护结构MRI数据库。结构和DTI数据 在成像核心中获得的数据将输入所有人类项目（1、3和4），以测试以下特定假设： 结构和功能的连接在前纹状体电路。提供的基础设施资源 成像核心是项目3和4不可或缺的，并有利于进入项目1的受试者;这些资源将 可用于未来几年可能访问UCLA CIDAR的未来儿科成像研究。成像 致力于促进ADHD和Tourette's神经生物学研究的核心将使我们能够解决 儿科成像中的一些更困难的问题，即，图像采集中的技术困难 在眶额区;分析发育中的大脑，可能包含结构差异， 异常;儿童大脑发育的变异性;以及扫描儿童的实际困难 认知控制障碍在成像研究的每个阶段都有核心资源，从设计和 通过数据分析获得的图像，将使不是成像专家的研究人员能够应用这些 方法，以其他发展障碍，并将提供资源，以评估新的影响， 行为和药物治疗对发育障碍患者大脑功能的影响。