Imaging Core

成像核心

• 批准号: 8136575
• 负责人: JAMES T. MCCRACKEN
• 金额: $ 14.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-31 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136575
• 关键词: Algorithms; Architecture; Area; Attention deficit hyperactivity disorder; Behavior Disorders; Behavioral; Biofeedback; Brain; Brain imaging; Child; Childhood; Computer software; Consult; Consultations; Corpus striatum structure; Data; Data Analyses; Data Quality; Databases; Development; Disease; Education; Electronics; Ensure; Environment; Experimental Designs; Feedback; Freedom; Functional Magnetic Resonance Imaging; Future; Gilles de la Tourette syndrome; Goals; Grant; Head; Human; Human Resources; Image; Image Analysis; Imaging technology; Individual; Laboratories; Magnetic Resonance Imaging; Magnetism; Methodology; Methods; Morphologic artifacts; Motion; Neurobiology; Physiologic pulse; Population; Predisposition; Protocols documentation; Quality Control; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Scanning; Services; Signal Transduction; Simulate; Solutions; Staging; System; Techniques; Testing; Training; Training Programs; Variant; base; cognitive control; data mining; desensitization; design; developmental disease; experience; feeding; image processing; improved; novel; programs; reconstruction; research study; simulation; software development; tool; user-friendly

The purpose of this core is to provide infrastructure resources for projects in the grant utilizing Magnetic Resonance Imaging, and to develop resources that may be shared for the current projects as well as future projects relevant to developmental disorders in fronto-striatal circuits. There will be four primary components of the Imaging Core: a technical sub-core, focused on testing and ensuring high image quality and integrating new technological developments developments including novel pulse sequences, parallel imaging technology, a head gradient set, rapid reconstruction algorithms, and simultaneous EEG/fMRI,as well as supporting structural MRi and DTI acqiuisition. A design and analysis sub-core will provide expertise for designing and implementing fMRi experiments, and analysis of fMRI, structural MRI and DTI data, and analysis. A behavioral training/desensitization unit will use a simulated MRi environment with biofeedback to desensitization pediatric subjects to the environment and track head motion to maximize the likelihood of successfully scanning difficult populations. Finally, an analysis and databasing unit will conduct fMRI analyses for CIDAR projects and manage and maintain a structural MRI database. Structural and DTI data acquired in the Imaging core will feed into all of the human projects (1,3,and 4) to test specific hypothesis of structural and functional connectivity in front-striatal circuits. The infrastructure resources provided by the Imaging Core is integral to projects 3 and 4 and benefits subjects entering Project 1; these resources will be available for future pediatric imaging studies that may access the UCLA CIDAR in future years. An imaging core dedicated to promoting research into the neurobiology of ADHD and Tourette's will enable us to tackle some of the more difficult problems in pediatric imaging, namely, the technical difficulties in image acquisition in orbito-frontal retgions; analysis of developing brains that may contain structural differences or abnormalities; variability in brain development in children; and practical difficulties in scanning children with disorders of cognitive control. Having core resources at every stage of the imaging study, from design and image acquisition through data analysis, will enable investigators who are not imaging experts to apply these methods to other developmental disorders, and will provide resources to evaluate the effects of new treatments, both behavioral and pharmacological, on brain function in developmental disorders.

该核心的目的是利用 Magnetic 为拨款项目提供基础设施资源 共振成像，并开发可以为当前项目以及未来共享的资源 与额纹状体回路发育障碍相关的项目。将有四个主要组成部分 成像核心：技术子核心，专注于测试和确保高图像质量和 整合新技术发展，包括新颖的脉冲序列、并行成像 技术、头部梯度集、快速重建算法、同步 EEG/fMRI，以及 支持结构性 MRi 和 DTI 采集。设计和分析子核心将为 设计和实施 fMRI 实验，以及分析 fMRI、结构 MRI 和 DTI 数据，以及 分析。行为训练/脱敏装置将使用具有生物反馈的模拟 MRi 环境来 让儿科受试者对环境脱敏并跟踪头部运动，以最大限度地提高 成功扫描困难人群。最后，分析和数据库单元将进行功能磁共振成像 分析 CIDAR 项目并管理和维护结构 MRI 数据库。结构和 DTI 数据 在成像核心中获得的数据将输入到所有人类项目（1,3,和4）中以测试特定的假设 前纹状体回路的结构和功能连接。提供的基础设施资源 Imaging Core 是项目 3 和 4 的组成部分，并且有利于进入项目 1 的科目；这些资源将 可用于未来几年可能访问加州大学洛杉矶分校 CIDAR 的儿科影像研究。影像学 致力于促进多动症和抽动秽语症神经生物学研究的核心将使我们能够解决 儿科影像中比较困难的一些问题，即图像采集的技术难点 在眶额区域；分析可能包含结构差异或的发育中大脑 异常；儿童大脑发育的变异性；以及扫描患有此病的儿童的实际困难 认知控制障碍。在成像研究的每个阶段都拥有核心资源，从设计到 通过数据分析获取图像，将使非成像专家的研究人员能够应用这些 方法治疗其他发育障碍，并将提供资源来评估新方法的效果 针对发育障碍中脑功能的行为和药物治疗。