Methods Core

研究方法核心，遵循CIDAR计划公告的主要目标，旨在 促进将创新的基础研究方法更全面地融入临床评估和治疗 竞技场。支持4个研究项目的每一个并推进CIDAR、RMC的总体目标 有3个具体目标，包括服务和科学任务：具体目标1：实施认知和 跨项目的神经生理评估方法，确保数据的一致性和高质量 收集、记录和分析；具体目标2：收集健康志愿者参考样本的数据 与项目一和项目四的人口统计特征相匹配(从而也与项目三相匹配)； 和具体目标3：使用心理测量学方法和建模，并结合 跨项目的信息，为认知能力的新分析和生物标志物的开发管道提供信息 这将对未来的治疗试验和转化性研究有用。化验的精炼将依赖于 确定：(A)判别效度(关于ADHD的诊断)；(B)结构(正常) 指标组合的有效性；(C)神经系统效应的同时有效性；(D)治疗效果的探索性交叉验证。RMC的工作人员是一支神经认知评估专家团队， 神经生理学评估、心理测量学和测量方法，具有丰富的经验 具体地说，在NIMH实施认知和神经生理服务核心功能 中心，以及高维、多模式数据源的科学集成，以实现推理 关于认知控制障碍中受影响的潜在神经系统过程。的长期目标 RMC包括开发和部署行为和神经生理学综合“小组” 在转化研究中交叉验证的分析，可用于下一代临床试验 儿童认知控制障碍的心理药理学和行为干预。RMC 还将向科学界免费传播这些新的分析和分析方法。

The Research Methods Core, following the principal goals of the CIDAR Program Announcement, aims to foster fuller integration of innovative basic research methods into the clinical assessment and therapeutics arena. Supporting each of the 4 research projects and advancing the overall goals of the CIDAR, the RMC has 3 specific aims comprising both service and scientific missions: Specific Aim 1: Implement cognitive and neurophysiological assessment methods across projects, guaranteeing uniformity and high quality in data collection, recording, and analysis; Specific Aim 2: Collect data on a reference sample of healthy volunteers matched to the combined demographic characteristics of projects I and IV (thereby also matching project III); and Specific Aim 3: Further refine measures using psychometric methods and modeling, and combining information across projects, to inform the development pipeline for novel assays and biomarkers of cognitive control that will be useful for future therapeutic trials and translational research. Assay refinement will rely on determinations of: (a) discriminant validity (with respect to the diagnosis of ADHD); (b) construct (nomothetic) validity for combinations of indicators; (c) concurrent validity with respect to neural systems effect; and (d) exploratory cross-validation with respect to treatment effects. The RMC is staffed by a team of experts in neurocognitive assessment, neurophysiological assessment, psychometrics and measurement methods, with extensive experience specifically in the implementation of cognitive and neurophysiological service core functions in NIMH Centers, and in the scientific integration of high-dimensional, multimodal data sources to enable inferences about underlying neural systems processes affected in cognitive control disorders. The long-term aims of the RMC include development and deployment of integrated "panels" of behavioral and neurophysiological assays, cross-validated in translational research, which can be used in clinical trials of next-generation psychopharmacological and behavioral interventions for pediatric disorders of cognitive control. The RMC will also disseminate these novel assays and analysis methods freely to the scientific community.