Methods Core

方法核心

• 批准号: 8136574
• 负责人: JAMES T. MCCRACKEN
• 金额: $ 26.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-31 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136574
• 关键词: Affect; Attention deficit hyperactivity disorder; Basic Science; Behavior Therapy; Behavioral; Biological Assay; Biological Markers; Characteristics; Childhood; Chronic; Clinical Trials; Clinical assessments; Cognitive; Communities; Data; Data Collection; Data Sources; Development; Diagnosis; Disease; Fostering; Future; Goals; Measurement; Measures; Methods; Mission; Modeling; NIH Program Announcements; National Institute of Mental Health; Neurocognitive; Process; Psychometrics; Research Methodology; Research Project Grants; Sampling; Services; System; Therapeutic; Therapy Clinical Trials; Tic disorder; Translational Research; Validation; cognitive control; experience; healthy volunteer; innovation; neurophysiology; next generation; novel; psychopharmacologic; relating to nervous system; treatment effect

The Research Methods Core, following the principal goals of the CIDAR Program Announcement, aims to foster fuller integration of innovative basic research methods into the clinical assessment and therapeutics arena. Supporting each of the 4 research projects and advancing the overall goals of the CIDAR, the RMC has 3 specific aims comprising both service and scientific missions: Specific Aim 1: Implement cognitive and neurophysiological assessment methods across projects, guaranteeing uniformity and high quality in data collection, recording, and analysis; Specific Aim 2: Collect data on a reference sample of healthy volunteers matched to the combined demographic characteristics of projects I and IV (thereby also matching project III); and Specific Aim 3: Further refine measures using psychometric methods and modeling, and combining information across projects, to inform the development pipeline for novel assays and biomarkers of cognitive control that will be useful for future therapeutic trials and translational research. Assay refinement will rely on determinations of: (a) discriminant validity (with respect to the diagnosis of ADHD); (b) construct (nomothetic) validity for combinations of indicators; (c) concurrent validity with respect to neural systems effect; and (d) exploratory cross-validation with respect to treatment effects. The RMC is staffed by a team of experts in neurocognitive assessment, neurophysiological assessment, psychometrics and measurement methods, with extensive experience specifically in the implementation of cognitive and neurophysiological service core functions in NIMH Centers, and in the scientific integration of high-dimensional, multimodal data sources to enable inferences about underlying neural systems processes affected in cognitive control disorders. The long-term aims of the RMC include development and deployment of integrated "panels" of behavioral and neurophysiological assays, cross-validated in translational research, which can be used in clinical trials of next-generation psychopharmacological and behavioral interventions for pediatric disorders of cognitive control. The RMC will also disseminate these novel assays and analysis methods freely to the scientific community.

研究方法核心遵循 CIDAR 计划公告的主要目标，旨在 促进创新基础研究方法更全面地融入临床评估和治疗 竞技场。支持 4 个研究项目中的每一个，并推进 CIDAR、RMC 的总体目标 有 3 个具体目标，包括服务和科学任务： 具体目标 1：实施认知和科学使命 跨项目的神经生理学评估方法，保证数据的一致性和高质量 收集、记录、分析；具体目标 2：收集健康志愿者参考样本的数据 与项目 I 和 IV 的综合人口特征相匹配（从而也与项目 III 相匹配）； 具体目标 3：使用心理测量方法和建模进一步完善措施，并结合 跨项目的信息，为认知的新测定和生物标志物的开发流程提供信息 控制将有助于未来的治疗试验和转化研究。测定精化将依赖于 确定： (a) 区分有效性（关于 ADHD 的诊断）； (b) 构造（名义） 指标组合的有效性； (c) 神经系统效应的同时有效性； (d) 治疗效果的探索性交叉验证。 RMC 拥有神经认知评估专家团队， 神经生理学评估、心理测量和测量方法，具有丰富的经验 特别是在 NIMH 认知和神经生理学服务核心功能的实施中 中心，并科学整合高维、多模式数据源以实现推理 关于受认知控制障碍影响的潜在神经系统过程。的长期目标 RMC 包括行为和神经生理学综合“面板”的开发和部署 检测方法，在转化研究中进行交叉验证，可用于下一代的临床试验 针对儿科认知控制障碍的心理药理学和行为干预。风险管理委员会 还将向科学界免费传播这些新颖的测定和分析方法。