STATISTICAL GENETICS AND TREATMENT ANALYSIS

统计遗传学和治疗分析核心旨在为研究设计、数据 分析和解释。所有核心成员都参与报告、演示文稿和 manuscnpts.另外。核心成员将继续努力制定新的统计方法， 将改进中心研究人员可用的分析技术。具体发展包括 在具有已知联系的区域中增加关联分析能力的方法以及 将错误发现率分配给微阵列实验中的多个基因表达测量。 核心B为所有五个项目提供服务。 相关性（参见说明）： 精神分裂症需要新的治疗策略来改善认知功能障碍和负性 症状和预防精神病的发展。该中心研究了一种烟碱乙酰胆碱 受体作为新的治疗靶点。研究结果用于设计一种新的药物治疗， 精神分裂症和婴儿发育过程中的预防性营养干预，两者都激活了这一点。 rpr.pntr>r

The Statistical Genetics and Treatment Analysis Core is designed to provide support in study design, data analysis, and interpretation. All Core members participate in preparation of reports, presentations, and manuscnpts. In addition. Core members will continue their efforts to develop new statistical approaches that will improve the analytic techniques available to Center investigators. Specific developments include methods to increase the power for association analysis in an area with a known linkage and methods to assign a false discovery rate to multiple gene expression measurements in a microarray experiment. Core B provides services to all five Projects. RELEVANCE (See instructions): New therapeutic strategies for schizophrenia are needed to improve cognitive dysfunction and negative symptoms and to prevent the development of psychosis. The Center investigates a nicotinic acetylcholine receptor as a new therapeutic target. Investigational results are used to design a new drug treatment for schizophrenia and a preventative nutnent intervention dunng infant development, both of which activate this rpr.pntr>r