Development of Trans Proteomics Pipeline, an Analysis Suite for Mass Spectrometry

描述（由申请人提供）：Trans-Proteomic Pipeline（TPP）是一套完整、免费且广泛采用的工具，用于分析串联质谱（MS/MS）蛋白质组学数据（“鸟枪蛋白质组学”）。TPP用于分析原始MS/MS数据，以识别和量化细胞和组织中的蛋白质及其丰度水平，从而可以调查围绕疾病原因识别、诊断技术开发和治疗方法开发的研究问题。TPP已经被数百名研究人员使用，对许多正在进行的研究项目至关重要。这笔赠款将使我们能够继续保持当前的功能，支持社区，并适应不断变化的蛋白质组学技术和技术。 公共卫生相关性：基于质谱的蛋白质组学已成为研究人类健康许多方面的关键，它允许研究疾病病理学，鉴定诊断标志物和开发治疗方法。Trans Proteomics Pipeline软件套件已成为众多进行基于质谱的实验的研究小组的基石。这笔赠款将使这一宝贵的软件的维护和发展，并使其继续使用和扩大其在整个研究机构，医院，大学部门和商业组织的相关性。

DESCRIPTION (provided by applicant): The Trans-Proteomic Pipeline (TPP) is a complete, free, and widely-adopted suite of tools for the analysis of tandem mass spectrometry (MS/MS) proteomics data ("shotgun proteomics"). The TPP is used for analyzing raw MS/MS data to identify and quantify proteins and their abundance levels in cells and tissues, allowing investigation of research questions surrounding the identification of causes of disease, the production of diagnostic techniques, and the development of treatments. The TPP is already in use by a community of hundreds of researchers, and is of fundamental importance to many ongoing research projects. This grant will allow us to continue to maintain current functionality, support the community, and adapt to changing proteomics technology and techniques. PUBLIC HEALTH RELEVANCE: Mass spectrometry based proteomics has become key to the study of many aspects of human health, it allows for the study of disease pathology, the identification of diagnostic markers and the development of treatments. The Trans Proteomics Pipeline software suite has become the cornerstone for numerous research groups who undertake mass spectrometry based experiments. This grant will enable the maintenance and evolution of this invaluable software, and enable its continued usage and expansion of its relevance throughout research institutions, hospitals, university departments and commercial organizations.