SBU Chemistry-Biology Interface Training Program

描述（由申请人提供）：本提案为石溪大学（SBU）博士前化学生物学培训计划申请资金。这个跨学科和跨部门的项目为从四个参与单位选择的博士生提供化学生物学培训机会：生物化学与结构生物学，化学，分子遗传学与微生物学，分子与细胞药理学研究生项目。参与的教师导师（29人）的研究兴趣包括传染病、癌症和毒理学、免疫学、发育生物学、能量收集、细胞信号传导、有机合成、物理有机化学、酶学和材料化学。学员接受化学和生物学的原理和技术的教育，其中包括三个学期的核心跨学科化学生物学课程。所有学员和导师都参加化学生物学和药物发现研究所的年度研讨会和海报会议。这种静修是促进学生和教师之间广泛互动的一种途径，学员群体保持了凝聚力。学生在学年期间每月与项目主任或导师共进一次午餐，作为对职业、项目评估和双向反馈的反馈论坛。受训者参加本国的研究生项目、研究俱乐部和系列研讨会，以在培训项目之外扩大知识和交流机会。在他们的第四年，学员与新闻系合作，将他们之前准备好的研究演讲转化为非科学家可以理解和欣赏的演讲，并在社区外展论坛上展示最引人注目的演讲。受训者邀请外部研讨会演讲者。负责任的研究行为的指导主要是通过参与“科学诚信”课程来实现的。通过SBU AGEP暑期本科生研究项目和广泛的外展活动，招募代表性不足的群体。参与CBI培训计划的导师人数为29人，第一年申请4个资助职位，随后几年申请8个资助职位。

DESCRIPTION (provided by applicant): This proposal requests funding for the predoctoral Chemical Biology Training Program at Stony Brook University (SBU). This interdisciplinary and interdepartmental Program offers chemical biology training opportunities for Ph.D. students selected from four participating units: the Biochemistry & Structural Biology, the Chemistry, the Molecular Genetics & Microbiology, and the Molecular & Cellular Pharmacology graduate programs. Participating faculty mentors (29) have research interests in infectious disease, cancer and toxicology, immunology, developmental biology, energy-harvesting, cell-signaling, organic synthesis, physical organic chemistry, enzymology, and materials chemistry. Trainees are educated in the principles and techniques of both chemistry and biology with a core interdisciplinary three-semester Chemical Biology course sequence. All trainees and mentors participate in the Institute of Chemical Biology and Drug Discovery annual symposium and poster session. This retreat is one avenue by which extensive interactions between students and faculty are fostered and the trainee group maintains a cohesive identity. The students meet for lunch with a Program Director or Mentor once per month during the academic year as a forum for feedback on careers, program assessment and two-way feedback. Trainees participate in their home graduate program research clubs and seminar series to broaden their knowledge and networking opportunities beyond the training program. In their fourth year, trainees work with Journalism faculty to convert their previously prepared research talks to presentations that non-scientists can understand and appreciate with the most compelling to be presented in a community outreach forum. Trainees invite outside seminar speakers. Instruction in the responsible conduct of research is carried out primarily through participation the course, "Scientific Integrity". Recruitment of underrepresented groups is achieved through the SBU AGEP summer undergraduate research programs and extensive outreach. The number of mentors participating in the CBI Training Program is 29 and four funded positions are requested in the first year and eight funded positions are requested in subsequent years. PUBLIC HEALTH RELEVANCE: Training of graduate students is essential for present and future discovery in biomedical research spanning cancer chemotherapy to new anti-infectives. This training program will provide students with training in chemical methods and biological methods that is necessary for developing new and better diagnostics and treatments for disease.