Program in Molecular and Cellular Biosciences

描述(由申请人提供)：本申请申请资助俄勒冈健康与科学大学分子与细胞生物科学(PMCB)专业博士前研究生的培训。这个跨学科的项目汇集了来自五个基础科学系(生物化学和分子生物学；细胞和发育生物学；分子和医学遗传学；分子微生物学和免疫学；生理学和药理学)、癌症生物学项目和附属研究机构的156名教师，为一年级和二年级的研究生提供成为成功的研究科学家所需的理论和实验室基础。这项提案将为目前在PMCB注册的115名博士生中的7名提供津贴，用于他们头两年的培训。这一应用领域的80名培训教师在生物物理、分子、细胞和开发方法方面的专业知识得到了国际认可，他们使用最先进的方法解决重要和引人注目的生物学问题。值得注意的是，研究生直接参与开创性的转化研究，范围从建立提高癌症存活率的新疗法到对干细胞生物学、神经发生和能量稳态的分子基础、蛋白质结构和化学生物学以及疫苗开发的新见解。我们的计划为符合条件的学生在第一年提供共同的、严格的教学基础，并在第二年学生开始专门化时继续基础。学生还参加系列研讨会、项目务虚会、教学，并可能参加科学会议。学生必须在第一年结束时成功通过综合笔试，并在第二年结束时通过资格考试，在这一考试中，他们准备并为原创研究方案辩护。随后，学生被正式录取到五个参与系中的一个，进行一项研究项目，以获得哲学博士学位。重要的是，OHSU充满活力的研究社区，加上邻近的基础和临床研究设施，为博士生提供了一个独特的机会，在他们的培训期间形成跨学科的合作，并获得对基础科学与健康相关的欣赏。相关性：本申请中建议的研究将为一年级和二年级研究生提供培训，使他们具备成为生物医学科学中成功的研究科学家所需的理论和实验室基础。学员将学习最先进的方法，以便他们可以参与开创性的基础研究和工作台到床边的研究，这些研究将提高未来的医疗保健质量。

DESCRIPTION (provided by applicant): This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health & Science University. This interdisciplinary program brings together 156 faculty from five basic science departments (Biochemistry and Molecular Biology; Cell and Developmental Biology; Molecular and Medical Genetics; Molecular Microbiology and Immunology; and Physiology and Pharmacology), the Cancer Biology Program and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support stipends for 7 Ph.D. students out of the 115 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students directly participate in ground-breaking translational research, ranging from establishment of new therapies that improve cancer survival to new insights into stem cell biology, the molecular basis of neurogenesis and energy homeostasis, protein structure and chemical biology, and vaccine development. Our program offers qualified students a common, rigorous didactic grounding for the first year and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provides a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic sciences. RELEVANCE: The studies proposed in this application will provide training for first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists in biomedical sciences. Trainees will learn state-of-the-art methods so that they may participate in ground-breaking basic and bench-to-bedside research that will improve the quality of healthcare in the future.