Diabetes and Endocrinology Research Center

总体描述(由申请人提供)： 哥伦比亚大学糖尿病和内分泌学研究中心自2003年5月开始运作。该中心将基础和转化性糖尿病研究与肥胖、动脉粥样硬化和心血管生物学研究方面的现有机构卓越中心整合在一起。DERC还与哥伦比亚大学的Naomi Berrie糖尿病中心完全整合，后者为基础和翻译研究、临床培训和社区推广提供场所，并吸引与糖尿病相关的慈善事业。哥伦比亚DERC的生物医学研究基地由72名由NIH、ADA和JDRF资助的研究人员组成。DERC支持五个共享的核心设施：基因组学(A)；激素和代谢物(B)；蛋白质表达和纯化(C)；胰岛生物学(E)；小鼠表型(F)。行政核心提供全面的后勤支助、财务监督以及研究工作和共享核心设施的整合。它还监督P/F计划的管理。此外，DERC为哥伦比亚大学其他研究领域的知名科学家提供进入糖尿病领域的机会和支持，并通过试点/可行性资助计划为年轻研究人员提供初始资金。DERC支持项目丰富活动，旨在提高哥伦比亚大学和纽约市的科学/学术社区对糖尿病研究的认识；它还促进了与大纽约地区学术机构的广泛互动。在最初的四年运作中，DERC努力推进NIDDK的重要使命：(I)在哥伦比亚大学和纽约市提高对高级临床和基础糖尿病研究的认识和兴趣；(Ii)加强对学生、研究员、学术和社区医生的培训和其他与糖尿病相关的教育机会；(Iii)吸引新的研究人员从事糖尿病研究；(Iv)提供最先进的核心设施，加强DERC成员的研究，并有助于开发糖尿病研究和护理的创新方法；(V)培育大学！(I)提供学术环境，以促进机构内部以及与其他疾病控制与预防中心和疾病控制与预防中心之间的信息交流；(Vi)推动将基础科学发现转化为临床护理和社区倡议，以改善糖尿病患者的健康；以及(Vii)利用NIDDK与地方和国家慈善和糖尿病倡导组织的资源，整合和扩大P&F赠款以及培训和教育计划。

DESCRIPTION, OVERALL (as provided by applicant): The Columbia University Diabetes & Endocrinology Research Center has been in operation since May 2003. The Center integrates basic and translational diabetes research with existing institutional centers of excellence in obesity, atherosclerosis and cardiovascular biology research. The DERC is also wholly integrated with Columbia University's Naomi Berrie Diabetes Center, which provides a venue for basic and translational research, clinical training and community outreach, and acts as a magnet for diabetes-related philanthropy. The Biomedical Research Base of the Columbia DERC is comprised of 72 NIH-, ADA- and JDRF-funded investigators. The DERC supports five shared core facilities: Genomics (A); Hormone & Metabolite (B); Protein Expression and Purification (C); Islet Biology (E); Mouse Phenotyping (F). An administrative Core provides overall logistical support, financial oversight and integration of research efforts and shared core facilities. It also oversees the administration of the P/F program. Additionally, the DERC provides established scientists in other research areas at Columbia University with the opportunity and support to enter the diabetes field, and makes available initial funding for young investigators through a pilot/feasibility grant program. The DERC supports program enrichment activities, designed to increase the awareness of diabetes research in the scientific/academic community at Columbia University and New York City; it also promotes extensive interactions with academic institutions in the greater New York area. Over the initial four years of operation, the DERC has endeavored to advance NIDDK's critical mission by: (i) raising awareness of and interest in advanced clinical and basic diabetes research at Columbia University and in New York City; (ii) enhancing training and other diabetes-related educational opportunities for students, fellows, academic and community-based physicians; (iii) attracting new investigators to diabetes research; (iv) providing state-of-the-art core facilities that enhance the research of DERC members and contribute to the development of innovative methods for diabetes research and care; (v) fostering a collegia! academic environment to facilitate information exchange within the institution and with other DERCs and DRTCs; (vi) providing impetus to translate basic science discoveries into clinical care and community initiatives to improve the health of people with diabetes; and (vii) leveraging NIDDK resources with local and national philanthropic and diabetes advocacy organizations to integrate and expand P&F grants, as well as training and educational programs.