Harvard Clinical Nutrition Research Center

总体描述（由申请人提供）： 在这个竞争性的更新申请中，我们建议建立一个已建立的机构资源，即哈佛临床营养研究中心，该中心主要设在哈佛医学院（HMS）的马萨诸塞州总医院，并与其他哈佛教学医院密切合作（CH、BIDMC、B&W），哈佛公共卫生学院营养系（HSPH）和波士顿的其他学术项目（波士顿大学和塔夫茨农业部）。该HCNRC的总体目标是提供高质量的研究，从而深入了解营养相关疾病的病因和发病机制，并改进营养护理的治疗方法。营养作为一门学科在哈佛有更多的知名度，因为1）在营养HMS和HSPH两个赋予椅子的创建，2）在HSPH和一个悬而未决的T32在HMS NIH资助的营养培训补助金，和3）在HMS营养部门的创建作为一项重大举措，以提供更多的营养教育在医学院课程和HMS医生和4）HCNRC。主要的具体目标是：1）提供与临床营养问题相关的生物学基础领域的研究; 2）促进临床营养研究和HMS，其教学医院和HSPH社区内的知识应用; 3）促进科学家和临床研究人员之间的互动，以显示推进临床营养科学的相关性; 4）吸引“基础”研究者进入临床营养领域，以促进环境和机制，发展新的研究者发起的研究。这些目标将通过难民专员办事处若干生物医学核心资源的运作得到促进：（a）基因组学;（B）形态学/组织培养/免疫学;（c）质谱法。支持上述目标的试点/可行性方案取得了巨大成功，特别强调以与理解和解决临床营养问题相关的方式探索基础科学家实验室工作扩展的建议。在这里，研究建议从基因水平延伸到综合性复杂患者的治疗。此外，还提出了一项教育充实计划，包括研讨会、短期课程、座谈会、辅导和直接学术/医院领域的正式教学课堂演示，并支持临床研究培训。

DESCRIPTION, OVERALL (provided by applicant): In this competing renewal application, we propose an established institutional resource, the Harvard Clinical Nutrition Research Center, principally based at the Massachusetts General Hospital of the Harvard Medical School (HMS) in close collaboration with other Harvard teaching hospitals (CH, BIDMC, B&W), the Department of Nutrition at the Harvard School of Public Health (HSPH) and other academic programs in Boston (Boston University and Tufts USDA). The overall goal of this HCNRC is to provide high quality research which will yield insights into the cause and pathogenesis of nutrition-related diseases and lead to improved therapeutic approaches to nutrition care. Nutrition as a discipline within Harvard has much more visibility because of the 1) creation of two endowed Chairs in Nutrition at HMS and HSPH, 2) a NIH-funded Nutrition Training Grant at HSPH and a pending T32 at HMS, and 3) the creation of a Division of Nutrition at HMS as a major initiative to provide more nutrition education in the medical school curriculum and HMS physicians and 4) the HCNRC. The major specific aims are: 1) to provide research in basic areas of biology relevant to problems in clinical nutrition; 2) to promote the study of clinical nutrition and application of knowledge derived there from within the HMS, its teaching hospitals and HSPH communities; 3) to promote interactions among scientists and clinical investigators to show relevance in advancing the science of clinical nutrition; and 4) to attract "basic" investigators into the domain of clinical nutrition to promote an environment and mechanism to develop new investigator-initiated research. These aims will be facilitated through the functioning of several HCNRC biomedical core resources; (a) Genomics; (b) Morphology/Tissue Culture/Immunology and (c) Mass Spectrometry. A pilot/feasibility program in support of the above aims has been enormously successful with a special emphasis on proposals to explore the extension of work emerging from laboratories of basic scientists in a manner relevant to the understanding and resolution of clinical nutrition problems. Here the research proposed extends from the level of the gene to treating of integrated, complex patients. Additionally, an education enrichment program is proposed including seminars, short-courses, colloquia, tutorials and formal didactic classroom presentations in the immediate academic/hospital area and to support training in clinical investigation.