Cancer Center Support Grant - Clinical Trials Reporting Supplement (CTRP)

描述（由申请人提供）：本申请要求韦恩州立大学底特律大都会Meyer L. Prentis综合癌症中心的NCI癌症中心支持补助金（CCSG）续期24-28年。由Karmanos癌症研究所管理的癌症中心，通过对其行政服务和组织的重大重组，新的领导和同行评审资金的大幅增加，重新建立了强有力的研究增长轨迹。癌症中心的项目反映了底特律大都会地区的癌症需求。这是一个工业化、城市和种族多样化的社区，医疗条件不利、社会经济地位低下的公民数量不成比例。该癌症中心长期致力于研究和临床服务，以解决癌症的预防，早期发现和治疗，特别是非洲裔美国人和阿拉伯裔美国人，他们因乳腺癌，前列腺癌和航空消化系统癌症而死亡率过高。我们的拨款要求支持5个研究项目，10个核心设施，5名高级领导，5名员工调查员，发展基金和相关行政支持。癌症中心已建立的研究项目有乳腺癌；发展治疗;分子生物学与人类遗传学；人口研究和预防，蛋白酶和癌症。CCSG还要求支持生物信息学、生物统计学、癌症中心信息学、临床试验办公室、细胞资源、基因组学、人体组织和病理学、共聚焦成像、流式细胞术和药理学等核心。我们的项目将基础、转化和临床研究与基于人口研究的癌症控制活动相结合。癌症中心将继续促进内部和跨学科的互动与合作，并利用CCSG发展基金招募新的研究人员，并开发具有高潜力的同行评审资金的转化研究项目。

DESCRIPTION (provided by applicant): This application requests renewal for years 24-28 of the NCI Cancer Center Support Grant (CCSG) for the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit at Wayne State University. The Cancer Center, which is managed by the Karmanos Cancer Institute, has re-established a strong trajectory of research growth with a significant re-organization of its administrative services and organization, new leadership and ant increase in peer-reviewed funding.The programs of the Cancer Center reflect the cancer needs of the greater Metropolitan Detroit area. This is an industrialized, urban and ethnically diverse community with a disproportionate number of medically disadvantaged, low socio-economic citizens. This Cancer Center has a long-standing and extensive commitment to both research and clinical services that address the prevention, earlier detection and treatment of cancer, particularly of African American and Arab American populations which experience disproportionate mortality from breast, prostate and aero-digestive cancers. Our grant requests support for five research programs, ten core facilities, five senior leaders, five staff investigators, developmental funds, and related administrative support. The Cancer Center's established research programs are Breast Cancer; Developmental Therapeutics; Molecular Biology and Human Genetics; Population Studies and Prevention, and Proteases and Cancer. CCSG support is also requested for Cores in Bioinformatics, Biostatistics, Cancer Center Informatics, Clinical Trials Office, Cell Resources, Genomics, Human Tissue and Pathology, Confocal Imaging, Flow Cytometry and Pharmacology. Our Programs are organized to integrate basic, translational, and clinical research with population research-based, cancer control activities. The Cancer Center will continue to foster intra- and inter-disciplinary interactions and collaborations, and to utilize CCSG developmental funds to recruit new investigators and to develop translational research programs that have a high potential for peer-reviewed funding.