Cardiovascular Research Training Program (CRTP)

描述（由申请人提供）：本心血管研究培训计划（CRTP）的目标是为有前途的博士前学生和高素质的MD或PhD博士后研究员提供基础心血管研究方面的出色培训。该计划包括来自凯斯西储大学6个基础科学和4个临床附属项目的27名培训师和9名初级培训师。招聘的教师以卓越的研究，充足的NIH资金和强大的研究空间而闻名。培训重点是将分子和细胞生物学、生理学、生物物理学、生物医学工程和成像的基本方法与健康和疾病中的心血管系统相关的机械问题和问题相关联，特别强调（a）血管发育、炎症和血栓形成（B）心脏肥大、衰竭和再生，（c）心脏电生理学和心律失常，（d）代谢和氧化还原调节，（e）信号传导和基因表达，和（f）心血管成像。博士前培训是通过招收已经在生物医学工程，细胞生物学，分子医学，营养学，药理学和生理学与生物物理学博士课程录取的学生完成的，并且他们已经从参与培训的教师中选择了论文顾问。这些部门计划提供的研究技能的基本课程和指导培训得到了CRTP特定组件的补充和增强。其中包括完成心血管生理学的必修研究生课程，心血管保健的令人兴奋的沉浸体验，参加每周研讨会系列，每月杂志俱乐部，以及由最近成立的Case Cardiovascular Research Institute（CVRI）组织的年度研究务虚会，和指导由CRTP教师委员会，其中包括高级培训师和初级非培训师教师谁是开发切割独立计划-心血管研究的边缘领域。博士后学员，谁是通过他们的招聘CRTP培训师实验室任命，也参加心血管保健沉浸，CVRI研讨会/务虚会/杂志俱乐部，和指导过程。该申请寻求6个职位为1-2年（3名博士前学员和3名博士后学员）和8个职位为3-5年（4名博士前和4名博士后学员）。

DESCRIPTION (provided by applicant): The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 27 trainers and 9 junior trainers from 6 basic science and 4 clinical affiliate programs at Case Western Reserve University. The recruited faculty is known for excellence in research, ample NIH funding, and robust research space. The training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Vascular development, inflammation, and thrombosis (b) Cardiac hypertrophy, failure, and regeneration, (c) Cardiac Electrophysiology and arrhythmias, (d) Metabolism and redox regulation, (e) Signal transduction and gene expression , and (f) Cardiovascular imaging. Predoctoral training is accomplished through enrollment of students who have already matriculated in PhD programs in Biomedical Engineering, Cell Biology, Molecular Medicine, Nutrition, Pharmacology, and Physiology & Biophysics, and who have selected a thesis advisor from among the participating trainers. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in the weekly seminar series, monthly journal club, and annual research retreat organized by the recently established Case Cardiovascular Research Institute (CVRI), and mentoring by a CRTP faculty committee that includes senior trainers and junior non-trainer faculty who are developing independent programs in cutting-edge areas of cardiovascular research. Postdoctoral trainees, who are appointed via their recruitment to CRTP trainer labs, also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. This application seeks 6 positions for years 1-2 (3 for predoctoral trainees and 3 postdoctoral trainees) and 8 positions for years 3-5 (4 predoctoral and 4 postdoctoral trainees).