Multidisciplinary Training in Translational Cardiovascular Research

描述(由申请人提供)： 本申请要求为转化性心血管研究中的多学科培训提供博士后和博士后资助。哥伦比亚大学医学中心的心血管转化研究培训计划旨在促进和确保心血管科学家的发展，这些科学家在心血管细胞生物学、生物物理学、遗传学和基因组学、生物和组织工程以及临床科学领域拥有广泛的基础知识。培训将在哥伦比亚大学内科和外科学院的克莱德和海伦·吴分子心脏病学中心和生理学和细胞生物物理学系，以及朱迪思·苏兹伯格基因组中心进行，朱迪思·苏兹伯格基因组中心包括NIH路线图功能基因组高通量筛选中心。针对纽约市大学本科生的少数族裔研究奖学金计划特别强调多样性，该计划为服务不足的少数族裔提供渠道，让他们在哥伦比亚大学的心血管培训项目中接受培训。分子心脏病学中心的成员包括基础研究人员和翻译研究人员，他们的主要任命是在医学、药理学、生理学和细胞生物物理学系内。该中心和生理系有完善的心血管研讨会系列和期刊俱乐部、联合实验室会议和务虚会，旨在鼓励合作和促进心血管研究的卓越。基础心血管生物学和翻译心血管生物学课程是基础心血管分子生理学和翻译心血管生物学的桥梁。学员将接触到不同的教职员工群体，包括外部机构和制药行业的几名教师，他们将在遗传学、细胞成像、高通量筛查等特定领域提供短期有针对性的指导，如果他们在单一实验室或一家机构接受培训，这些指导是不可能的。拟议的计划将使用跨学科方法，特别强调前瞻性思维科学，包括功能基因组学、化学生物学、结构生物学、组织工程、生物工程和分子生理学，所有这些都将在一些世界领先的心血管科学家领导的现有心血管实验室的背景下进行。

DESCRIPTION (provided by applicant): This application requests pre-doctoral and post-doctoral funding for Multidisciplinary Training in Translational Cardiovascular Research. The training program in Translational Cardiovascular Research at Columbia University Medical Center is conceived to enhance and ensure the development of cardiovascular scientists who have broadly-based knowledge in the fields of Cardiovascular Cell Biology, Biophysics, Genetics and Genomics, Bio- and Tissue-Engineering and Clinical Sciences. The training will be based within the Clyde and Helen Wu Center for Molecular Cardiology and Department of Physiology and Cellular Biophysics at Columbia University College of Physicians & Surgeons, and the Judith Sulzberger Genome Center which includes an NIH Roadmap Functional Genomics High Throughput screening center. Particular emphasis has been placed on diversity through a Minority Research Fellowship Program for undergraduates in New York City Universities that serves as a pipeline for underserved minorities to train in the cardiovascular training program at Columbia. Members of the Center for Molecular Cardiology include basic and translational researchers whose primary appointments are within the Departments of Medicine, Pharmacology, and Physiology and Cellular Biophysics. The Center and the Department of Physiology have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings, and retreats, that are designed to encourage collaborations and foster excellence in cardiovascular research. A course in basic and translational cardiovascular biology bridges fundamental cardiovascular molecular physiology with translational cardiovascular biology. Trainees will be exposed to a diverse group of faculty, including several at outside institutions and in the pharmaceutical industry who will provided short-term targeted mentoring in specific areas such as genetics, cell imaging, high throughput screening, which would not be possible if they trained in a single laboratory or at one institution. The proposed program will use an interdisciplinary approach with special emphasis on forward thinking science including functional genomics, chemical biology, structural biology, tissue engineering, bioengineering and molecular physiology all in the context of established cardiovascular laboratories headed by some of the world's leading cardiovascular scientists.