Mid-Career Mentoring Award for Patient-Oriented Research in Aging

描述（由申请人提供）：我，Edward R. Marcantonio， MD， SM，是一名董事会认证的老年病学专家和以患者为导向的老龄化研究人员，哈佛医学院（HMS）医学副教授，贝斯以色列女执事医疗中心（BIDMC）普通医学和初级保健部研究主任。我职业生涯的长期目标是开展面向患者的研究（patient-oriented research， POR），以提高住院老年人的护理质量和结果，并为对老年人的POR感兴趣的新研究者提供指导。在过去的16年里，我建立了一个成功的、独立的、由美国国立卫生研究院资助的研究项目，重点研究谵妄（急性精神错乱），这是住院老年人中一种常见的、病态的、昂贵的疾病。我进行了一系列观察性和干预性研究，旨在提高诊断水平，针对有风险的个体，确定可改变的风险因素，并测试干预策略，以减少谵妄的发生率、严重程度和持续时间。通过这些研究，我获得了进行高质量POR和指导新研究者所需的知识和技能，并因我在指导方面的出色表现获得了两个著名奖项。在此背景下，K24奖项的主要目标是：1。继续建立一个研究项目，以提高住院老年谵妄患者的护理质量和结果。这一目标将通过我目前资助的研究来实现，包括nia资助的R01题为3D-CAM：衍生和验证谵妄的3分钟诊断评估，以及我的新研究，本应用程序中描述的谵妄项目的生物标志物发现。收到K24将使我能够更有效地利用这些研究和其他正在进行的工作来支持受训者的工作，他们将反过来扩大我的研究计划。2. 建立一个指导计划，将扩大老年POR在BIDMC和HMS，重点放在谵妄和相关条件。这一目标将通过对对POR有浓厚兴趣的年轻研究人员进行结构化的个人指导来实现。受保护的指导时间将由K24奖提供。3. 扩大我的指导计划，包括围绕谵妄的生物标志物发现的翻译，跨学科的工作，以及生物标志物的应用，以改善谵妄老年人的风险分层，诊断和预后。这一目标将通过我的新研究项目、职业发展活动和跨学科合作来实现，这些将通过获得K24奖而得到促进。HMS和BIDMC的普通医学和老年医学部门提供的卓越的学术环境和优秀的机构支持将极大地促进我的目标。

DESCRIPTION (provided by applicant): I, Edward R. Marcantonio, MD, SM, am a board-certified geriatrician and patient-oriented aging researcher, Associate Professor of Medicine at Harvard Medical School (HMS) and Director of Research in the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center (BIDMC). The long term objectives of my career are to conduct patient-oriented research (POR) to improve the quality of care and outcomes of hospitalized older adults, and to provide mentoring to new investigators interested in POR in aging. Over the past 16 years, I have built a successful, independent, NIH-funded program of research focused on delirium (acute confusion), a common, morbid and costly condition in hospitalized older adults. I have conducted a series of observational and interventional studies designed to improve diagnosis, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. Through these studies, I have gained the knowledge and skills necessary to conduct high quality POR and to mentor new investigators, and have been recognized for my excellence in mentoring with two prestigious awards. In this context, the primary objectives of this K24 Award are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium. This objective will be accomplished through my currently funded studies, including an NIA-funded R01 entitled 3D-CAM: Deriving and validating a 3-Minute Diagnostic Assessment for Delirium, and my new research, a Biomarker Discovery for Delirium project described in this application. Receipt of the K24 will enable me to more effectively leverage these studies and other ongoing work to support the work of trainees, who will in turn expand my research program. 2. To build a mentorship program that will expand POR in aging at BIDMC and HMS, with a focus on delirium and related conditions. This objective will be accomplished through structured, individual mentorship of young investigators with a strong interest in POR. Protected time for mentorship will be provided by the K24 award. 3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. This objective will be accomplished through my new research project, career development activities, and interdisciplinary collaborations that will be facilitated by receipt of the K24 award. My objectives will be greatly facilitated by the superb academic environment and outstanding institutional support provided by HMS and the BIDMC Divisions of General Medicine and Gerontology. PUBLIC HEALTH RELEVANCE: Delirium (acute confusion) complicates over 25% of the more than 12 million hospital stays per year of older adults in the U.S., leading to substantial morbidity, mortality, and cost. The goals of this K24 Award are to conduct patient-oriented research (POR) in the field of delirium, and to train new investigators in POR focused on improving diagnosis, monitoring, and treatment of delirium. The ultimate goal of this Award is to expand research activity and capacity in this critically important area, thereby improving the health of seniors.