MRI-Guided Cardiac Focused Ultrasound Ablation

摘要 本项目的长期目标是开发一种非侵入性治疗肥厚型梗阻性心肌病的方法 （HOCM）。聚焦超声（FUS）是一种很有前途的无创热消融技术。建议的努力 这里讨论了在心脏中使用聚焦超声治疗的主要技术挑战。具体而言，我们的目标是 1)评价磁共振（MR）引导的相控阵聚焦超声（FUS）治疗对非 侵入性消融心肌，包括在存在射束路径阻塞时靶向心脏的策略， 胸腔和肺部，并使消融与心脏节律同步，2）开发强大的实时靶向， 使用磁共振成像进行心脏温度监测，以及3）进行初始测试和评估， the system.我的近期职业目标是开发必要的FUS消融和MR成像策略， MR引导下FUS消融是治疗HOCM的一种无创性替代方法。一个独特的研究环境是有益的- 通过放射科、心脏科和电气科之间的跨学科合作， 斯坦福大学工程系。这个机会提供了深入了解心脏生理的能力- 除了进一步发展我在心脏磁共振成像方面的专业知识外，我还学习了心脏病学。我的职业规划包括 在聚焦超声消融的原理方面获得了相当多的专业知识，包括用有限 元件模型、FUS体模设计和心脏MR温度成像。我的长期职业目标是确保 终身教职，以便我可以继续为MR引导聚焦超声治疗领域做出贡献 并通过探索新的、侵入性较小的治疗方案，对患者护理产生根本性影响。

Abstract The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non- invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation of the system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MR-guided FUS ablation a noninvasive alternative for the treatment of HOCM. A unique research environment is avail- able to me through interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. This opportunity affords the ability to gain a deep understanding of cardiac physi- ology in addition to further developing my expertise in cardiac magnetic resonance imaging. My career plan includes gaining considerable expertise in the principles of focused ultrasound ablation, including field simulations with finite element models, FUS phantom design, and cardiac MR temperature imaging. My long-term career goal is to secure a tenure-track faculty position so that I can continue to contribute to the field of MR-guided focused ultrasound therapies and to make a fundamental impact on patient care by exploring new, less invasive treatment options.