MR-GUIDED FOCUSED ULTRASOUND ABLATION THROUGH THE RIBCAGE

MR 引导穿过胸腔的聚焦超声消融术

• 批准号: 8169896
• 负责人: VIOLA RIEKE
• 金额: $ 3.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169896
• 关键词: Abdomen; Ablation; Acoustics; Area; Attenuated; Cartilage; Chest; Computer Retrieval of Information on Scientific Projects Database; Disease; Elements; Focused Ultrasound Therapy; Funding; Grant; Heart; Heating; Human; Image; Individual; Institution; Life; Location; Measures; Methods; Necrosis; Obstruction; Positioning Attribute; Research; Research Personnel; Resources; Shapes; Sonication; Source; Spottings; Surface; Temperature; Tissues; Transducers; United States National Institutes of Health; alternative treatment; bone; electric impedance; rib bone structure; soft tissue

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: In recent years, MR-guided focused ultrasound (FUS) ablation has shown promise as a non-invasive alternative for the treatment of various diseases. For FUS applications in the upper abdomen and chest, a major limitation is the restricted acoustic window for FUS delivery, due to the higher acoustic impedance of thoracic bone and cartilage compared to soft tissues. Here, we investigate if a human size ribcage provides enough acoustic window to ablate tissue in the heart. Methods and Discussion: The results showed that the maximum ablation temperature varied with the amount of rib obstruction. For comparison, no rib obstruction resulted in a temperature of 45¿C. Areas with less than approximately 40% rib obstruction reached temperature rises of more than 30¿C, sufficient to create tissue necrosis in living tissue (final temperature > 55¿C). However, temperature elevations as low as 5¿C were measured in areas with more than 80% beam path obstruction by the ribs. In addition, an offset from the selected sonication location and the location of the maximum temperature rise was found for most sonications (average of 5 mm in the imaging plane). This suggests that the ribs not only attenuate the heating spot but also influence its position and shape. Surface heating of the ribcage was observed, which highlights the need for adaptive mechanisms such as turning off individual transducer elements with beam paths obstructed by ribs.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 简介：近年来，MR 引导的聚焦超声 (FUS) 消融已显示出作为治疗各种疾病的非侵入性替代方案的前景。对于上腹部和胸部的 FUS 应用，一个主要限制是 FUS 传输的声窗受限，因为与软组织相比，胸骨和软骨的声阻抗较高。在这里，我们研究人类大小的胸腔是否提供足够的声窗来消融心脏中的组织。 方法与讨论：结果表明，最高消融温度随肋骨阻塞量的不同而变化。为了进行比较，没有肋骨阻塞导致温度为 45°C。肋骨阻塞率低于约 40% 的区域温度升高超过 30°C，足以在活体组织中产生组织坏死（最终温度 > 55°C）。然而，在超过 80% 的光路被肋阻挡的区域，测得温度升高低至 5°C。此外，对于大多数超声处理，发现与所选超声处理位置和最大温升位置的偏移（成像平面中的平均 5 毫米）。这表明肋不仅减弱了加热点，而且还影响其位置和形状。观察到胸腔的表面加热，这凸显了对自适应机制的需求，例如关闭受肋骨阻碍的光束路径的各个换能器元件。