Interventions for Body Dysmorphic Disorder

描述(由申请人提供)：项目摘要：这是第三次也是最后一次提交竞争续签申请，申请K24职业中期研究员奖，以患者为中心的研究。这一奖项将为继续指导初学者提供必要的支持，并将极大地加强我以患者为导向的研究。我目前的K24奖将于2006年8月结束，它为我的指导提供了关键支持，并使我能够发展新的研究技能。与K24的宗旨一致，在我目前的获奖期间，我已经撰写了85份出版物(81份已出版或正在出版，4份已提交)，其中许多是由学员共同撰写的。我还获得了额外的联邦资金，为35名学员提供了研究指导，并参加了许多额外的国家和地方指导和领导活动。我是为数不多的身体变形障碍(BDD)研究人员之一，BDD是一种异常严重、相对常见且研究不足的障碍，与自杀念头、自杀企图和完全自杀的比率极高有关。我的主要职业目标是1)继续以患者为导向的BDD研究(特别是其治疗)，以及2)继续招募和指导以患者为导向的研究初学者。我的研究计划包括目前联邦政府资助的BDD干预研究。获奖期间的新研究将主要集中在开发和测试创新的新疗法上。这些研究将包括一项比较药物疗法和CBT的疗效研究，以及为自杀倾向更高的患者开发一种联合治疗方法。几项研究将包括翻译成分。我的指导计划将主要集中在干预研究以及特别是BDD上。我在开发和测试药理学和心理社会干预方面积累了专业知识，这在干预者中相对不常见，这加强了我的指导。我将继续指导个别辅导对象，并参加国家和地方的辅导活动。我的指导计划还包括提交关于强迫症和BDD的干预和转译(基础-临床)研究的T32研究培训拨款申请。这一地区的初级调查人员非常有限。续签我的K24奖将为我的指导提供必要的支持，并使我能够继续我富有成效的研究计划。与公共卫生的相关性：BDD虽然没有得到足够的认识，但相对常见。与大多数其他严重的精神疾病相比，它与更大的自杀倾向和更差的功能和生活质量有关。至关重要的是，继续进行BDD研究，并通过指导培养一支研究队伍来继续这项工作。我在更广泛的干预研究方面的指导将有助于满足这一至关重要领域对未来研究人员的迫切需求。

DESCRIPTION (provided by applicant): Project Summary: This is the third and final submission of a Competing Renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research. This award will provide essential support for continued mentoring of beginning investigators and will greatly enhance my patient-oriented research. My current K24 award, which ends in 8/06, has provided critical support for my mentoring and has enabled me to develop new research skills. Consistent with the purpose of the K24, during my current award, I have written 85 publications (81 published or in press, and 4 submitted), many of which were co-authored by mentees. I have also obtained additional federal funding, provided research mentoring to 35 mentees, and participated in many additional national and local mentoring and leadership activities. I am one of the very few researchers of body dysmorphic disorder (BDD), an unusually severe, relatively common, and understudied disorder that is associated with markedly high rates of suicidal ideation, suicide attempts, and completed suicide. My primary career goals are to 1) continue patient- oriented research on BDD (in particular, its treatment), and 2) continue to recruit and mentor beginning researchers in patient-oriented research. My research plan includes current federally funded intervention studies for BDD. New research during the award period will focus primarily on developing and testing innovative new treatments. These studies will include an efficacy study comparing pharmacotherapy and CBT, and development of a combined treatment for more highly suicidal patients. Several studies will include translational components. My mentoring plan will focus primarily on interventions research as well as BDD specifically. I have developed expertise in developing and testing both pharmacologic and psychosocial interventions, which is relatively uncommon among interventionists and which enhances my mentoring. I will continue to mentor individual mentees and participate in national and local mentoring activities. My mentoring plan also includes submitting a T32 research training grant application on interventions and translational (basic-clinical) research on OCD and BDD. This area has a very limited pipeline of beginning investigators. Renewal of my K24 award will provide essential support for mentoring and enable me to sustain my fruitful program of research. Relevance to Public Health: BDD, although underrecognized, is relatively common. It is associated with greater suicidality and poorer functioning and quality of life than most other serious mental illnesses. It is critically important to continue BDD research and, through mentoring, develop a cadre of researchers to continue this work. My mentoring on interventions research more broadly will help meet a pressing need for future researchers in this critically important area.