High School Student NeuroResearch Program (HSNRP)

描述(由申请人提供)：亚利桑那大学(UA)高中生神经研究计划(HSNRP)将引进、培训和培养越来越多有才华的亚利桑那州高中生，包括未被充分代表的少数族裔，从事正常和异常神经系统、神经疾病和中风的基础、翻译和临床研究，并鼓励追求高级研究经验和健康/科学相关职业。我们将利用联邦政府长期资助的多学科/多专业弱势高中生和医学生暑期研究项目强大的基础设施、有效的招聘策略、高水平的学生/教师导师参与、团队精神和出色的实习生生产力，为这一新的专门神经研究(NR)项目开发培训模式。在接下来的5年里，每年有12到14名全日制暑期高中实习生将获得更多密切指导的神经研究(NR)经验；2-4名将被重新任命为高级NR的本科生。这些将被整合到一个创新的探究式夏季医学无知研究所(SIMI)中，将生物医学知识和未知(“我们知道我们不知道的，不知道我们不知道的，认为我们知道但不知道的”)与NR专题交织在一起，并通过全年定期的浓缩活动来维持。SIMI强调“翻译翻译”，包括高中水平的病理生物学简介、专题研讨会、实验室/领导力/多媒体技能工作坊、临床相关性、社交网络和职业建议。一个独特的虚拟临床研究中心/问卷室构成了培训和国内/国际网络的中心。在基础和临床部门和专业英才中心内，并由精力充沛的HSNRP领导团队和咨询委员会监督，高中生研究将涵盖跨学科主题，以及神经生物学/疾病的体内、体外、原位、硅胶和建模方法，包括帕金森、阿尔茨海默病、尼曼-皮克C疾病、肌萎缩侧索硬化症、癫痫、艾滋病毒脑病、头部创伤、脑积水、肌肉营养不良、疼痛/成瘾药理学、分子精神病学、认知、脑发育、衰老、智力低下、血脑屏障/神经保护、神经成像、神经基因组/蛋白质组学、神经工程、脑深部刺激、脑癌症、脑血管疾病、中风和康复。基于我们约25年的跟踪记录和亚利桑那州大量不同类型的弱势学生的既定渠道，反映在迄今跟踪的474名接受SIMI培训的高中生中，许多学生从事基础/临床神经研究，我们预计HSNRP将：培养一个不断扩大的不同研究人员、医生和其他卫生专业人员的网络；为神经研究管道和企业做出贡献；并通过社区参与提高“神经健康”素养。正在进行的短期和长期评价，包括调查、数据库登记和职业组合，将记录培训模式的效力并促进联网。 与公共健康相关：该提案将制定和实施一项示范计划，以招募、培训和指导越来越多的不同/弱势(包括代表不足的少数族裔)高中生进行生物医学研究，主要针对神经科学、神经疾病和中风。我们将促进职业发展渠道，以促进网络、留任和职业发展，从而为NIH路线图目标(创建未来多样化的临床研究团队)和NINDS的战略计划做出贡献，该战略计划推动神经科学领域的医学发现从工作台到床边到社区的转化。

DESCRIPTION (provided by applicant): The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) will introduce, train, and nurture a growing cadre of diverse talented Arizona high school students including under-represented minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke as well as encourage pursuit of advanced research experiences and health/ science-related careers. We will leverage the strong infrastructure, effective recruitment strategies, high level of student/faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our long-standing federally funded multidisciplinary/multispecialty disadvantaged high school student and medical student summer research programs to develop the training model for this new specialized NeuroResearch (NR) program. Twelve to 14 full-time summer high school trainees annually for the next 5 years will be offered an expanding menu of closely mentored NeuroResearch(NR) experiences; 2-4 will be reappointed as under- graduates for advanced NR. These will be integrated into an innovative inquiry-based Summer Institute on Medical Ignorance (SIMI) interweaving biomedical Knowns and Unknowns ("what we know we don't know, don't know we don't know, and think we know but don't") with featured NR topics and sustained by periodic enrichment activities year round. SIMI emphasizes "translating translation" and includes a high school level brief Introduction to Pathobiology, topical seminars, laboratory/leadership/multimedia skill workshops, clinical correlations, social networking, and career advising. A unique Virtual Clinical Research Center/Questionarium forms a centerpiece for training and national/international networking. Within basic and clinical departments and specialized Centers of Excellence and overseen by an energetic HSNRP Leadership Team and Advisory Committee, high school student research will encompass cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/ addiction pharmacology, molecular psychiatry, cognition, brain development, senescence, mental retardation, blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain cancer, cerebrovascular disease, stroke, and rehabilitation. Based on our ~25-year track record and established access to large diverse pools of disadvantaged Arizona students reflected in 474 SIMI- trained high school students followed to date with many in basic/clinical NeuroResearch, we expect HSNRP to: cultivate an expanding network of diverse researchers, physicians and other health professionals; contribute to the NeuroResearch pipeline and enterprise; and improve "neurohealth" literacy through community engagement. Ongoing short-term and long-term evaluation including surveys, database registry and career portfolios will document efficacy of the training model and promote networking. PUBLIC HEALTH RELEVANCE: This proposal will develop and implement a model program to recruit, train and mentor a growing cadre of diverse/disadvantaged (including under-represented minority) high school students in biomedical research broadly targeting neurosciences, neurological disorders and stroke. We will energize a career pipeline to promote networking, retention and career progression, thereby contributing to the NIH Roadmap goals of creating the diverse clinical research teams of the future and NINDS's Strategic Plan of advancing translation of medical discoveries in the neurosciences from bench to bedside to community.