MULTIMODAL WORKING MEMORY ASSESSED WITH EVENT-RELATED POTENTIAL RECORDINGS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 工作记忆(WM)指的是一种神经系统，它持有和处理相对少量的待决动作信息，对足智多谋的认知加工至关重要。显然，选择性注意机制与工作记忆相互作用，从编码来自所有通道的相关刺激到协调信息保持导致目标导向行为。之前的大量研究都集中在工作记忆能力的有限上，对工作记忆本质的有趣见解来自对临床人群(如精神分裂症患者)的个体间差异和注意力相关能力缺陷的研究。探索可视化WM的经典过程是简单而优雅的：以简短的间隔两次呈现不同复杂性的双边数组。参与者的任务是指出这两个演示在特定功能方面是相同的还是不同的。这项任务在刺激很少的情况下很容易，但随着阵列中元素数量的增加，这项任务变得更加困难。WM的容量通常使用行为任务来估计。然而，最近，Vogel和Machizawa(2004)报道了一种电生理测量，该测量与视觉辨别任务中WM中持有的信息量高度相关。这些作者在线索注意范式中使用了带有不同数量条的双边视觉阵列，他们的参与者必须寻找被关注一侧其中一个方块的颜色变化。我计划使用行为数据和高密度168个通道的EEG/ERP记录，通过改变空间位置的数量而不是颜色的变化来研究他们最初发现的普遍性。 初步的行为数据显示，听觉和视觉的工作记忆能力作为刺激复杂性的函数具有惊人的相似性，受此鼓舞，我还将使用听觉、视觉和视听刺激来研究听觉和视觉工作记忆的容量限制。这些结果将有助于澄清一个长期存在的争议，即WM的内容是否具有特定的形态。 Ed Vogel博士是Teder-Salejarvi博士的个人项目导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Working memory (WM) refers to a neural system that holds and manipulates a relatively small amount of information for pending action and is crucial for resourceful cognitive processing. Clearly, selective attention mechanisms interact with WM from encoding relevant stimuli from all modalities to orchestrating retention of information resulting in goal-oriented behavior. A large body of previous research has focused on the limited capacity of WM and intriguing insights about the nature of WM come from studies investigating inter-individual differences and attention-related capacity deficits in clinical populations like patients suffering from schizophrenia. The classic procedure to probe visual WM is straightforward and elegant: A bilateral array of varying complexity is presented twice separated by a brief interval. The participants' task is to indicate whether both presentations are identical or different with respect to a particular feature. This task is easy with few stimuli but becomes more difficult as the number of elements in the array is increased. The capacity of WM has typically been estimated using behavioral tasks. Recently, however, Vogel and Machizawa (2004) reported an electrophysiological measure that is highly correlated with the amount of information being held in WM during a visual discrimination task. These authors used bilateral visual arrays with various numbers of bars in a cued attention paradigm and their participants had to look for a change in color of one of the squares on the attended side. I plan to investigate the generality of their original findings using behavioral data and high-density 168-channel EEG/ERP recordings by varying the number of spatial locations instead of changes in color. Encouraged by preliminary behavioral data that revealed striking similarities between auditory and visual WM capacity as a function of stimulus complexity, I will use also auditory, visual, and audio-visual stimuli to investigate the capacity limits of auditory and visual WM. These results will help to clarify a long-standing controversy as to whether the contents of WM are modality-specific or not. Dr. Ed Vogel served as Dr. Teder-Salejarvi's Individual Project Mentor.