IMAGING CORE

简历上写道，评审员们对《创新与尖端》充满热情。 成像核心，但也表明了一些弱点，主要是缺乏建立 双光子显微镜以及对雇用和培训所需高级专家的能力的担忧 为工厂配备工作人员。个别审查中的关切涉及核心管理的细节。每一个 这些问题在修订后的计划中得到解决： 首先，我们提供了建造双光子显微镜的详细时间表，这将需要 4个月左右。时间表是根据最近建造相同设施的经验制定的。 其次，我们聘请了高级别的影像专家。希瑟·J·罗斯博士拥有 听觉细胞神经生理学，目前是伊恩·帕克博士的博士后研究员 用双光子显微镜观察钙离子的瞬变过程。她对双光子有相当丰富的经验 成像，包括建造仪器和进行实验，在体内和体外。她是 非常有资格，并且对这个职业机会充满热情。 最后，还提供了有关核心管理的其他详细信息。特别是，我们将建立 一个咨询委员会，协助核心主任Karina Cramer博士制定和评估 使用核心资源的优先事项。P30主任和执行委员会将提供指导 用于设定优先顺序和评估资源使用情况。咨询委员会将每季度开会一次，并 将由永久成员帕克博士、罗斯博士和另一名成员组成 从核心用户中选择。最后，我们提供了关于缺乏类似的 UCI校园内的设施。

The resume notes that the reviewers were enthusiastic about the "innovative and state-of-the-art" Imaging Core, but also indicates some weaknesses, primarily the lack of a timetable for building the 2-photon microscope and concern over the ability to hire and train the high-level specialist needed to staff the facility. Concerns in individual reviews relate to the details of Core administration. Each of these issues is addressed in the revised plan: First, we provide a detailed timetable for the construction of the 2-photon microscope, which will take about four months. The timetable is based on recent experience constructing identical facilities. Second, we have recruited the high-level Imaging Specialist. Dr. Heather J. Rose has a Ph.D. in auditory cellular neurophysiology and currently is a postdoctoral fellow with Dr. Ian Parker studying Ca2+ transients using a 2-photon microscope. She has considerable experience with 2-photon imaging, including building instruments and conducting experiments, in vivo and in vitro. She is eminently qualified and is enthusiastic about this professional opportunity. Finally, additional details regarding Core administration are provided. In particular, we will establish an Advisory Committee to assist the Core director, Dr. Karina Cramer, in setting and evaluating priorities for use of Core resources. The P30 Director and Executive Committee will provide direction for setting priorities and evaluating use of resources. The Advisory Committee will meet quarterly and will consist of Dr. Parker as a permanent member, Dr. Rose, and an additional member to be selected from among Core users. Finally, we have provided information on the lack of similar facilities on the UCI campus.