An Interdisciplinary Approach to HIV and Other Infectious Diseases of Drug Users

描述(由申请人提供)：P30药物使用和艾滋病毒研究中心(CDUHR)的这份续签申请侧重于“针对吸毒者的艾滋病毒和其他传染病的跨学科方法”。目前的中心强调影响艾滋病毒预防和传播的社会行为因素，并在这一领域做出了重要贡献。我们现在建议扩大我们的研究范围，从更广泛的角度研究吸毒者及其社区的临床传染病(例如，性传播感染和丙型肝炎)，并通过将临床传染病与社会行为流行病学研究结合起来，加强我们的跨学科重点。根据吸毒者领域新出现的研究需求，我们将更多地关注(1)艾滋病毒的性传播；(2)丙型肝炎病毒和艾滋病毒/丙型肝炎病毒的混合感染；(3)获得服务的差距；(4)国内和国际艾滋病毒研究中研究不足的主题，包括感染的地理差异，处理性传播的创新干预措施，以及了解社会和行为过程如何与流行病学和病原体特征相互作用。我们还将加强社区团体、临床传染病专家和社会行为研究人员之间的研究成果的传播和合作。该中心的总体目标将是在吸毒者中加强关于艾滋病毒和相关传染病的跨学科研究。CDUHR还将作为传播新的研究方法和成果的资源。该中心将为培训和咨询提供研究基础设施，以提高研究人员的生产率和协作，提高研究效率，并创造协同效应，从而在跨学科研究中发展新的研究人员、新的倡议和新的知识。CDUHR-III将通过5个核心实现这些目标：(1)传染病--作为关于吸毒者的临床传染病和相关保健问题的资源；(2)理论综合--整合来自不同学科的理论；(3)跨学科研究方法--促进研究设计和分析方面的卓越；(4)传播，为服务提供者受众开发传播机制；以及(5)管理--提供科学领导，并确保核心、项目和调查人员之间的协作和协同。

DESCRIPTION (provided by applicant): This renewal application for the P30 Center for Drug Use and HIV Research (CDUHR) focuses on "An Interdisciplinary Approach to HIV and Other Infectious Diseases of Drug Users". The current Center emphasizes socio-behavioral factors influencing HIV prevention and transmission and has made important contributions to the field. We now propose to expand our scope of research, to a wider perspective on clinical infectious diseases (e.g., sexually transmitted infections [STIs] and Hepatitis C [HCV]) in drug users and their communities and strengthen our interdisciplinary focus by integrating clinical infectious diseases with socio-behavioral-epidemiologic research. Based on emerging research needs in the field regarding drug users, we will focus more on (1) sexual HIV transmission; (2) HCV and HIV/HCV co-infection; (3) service access disparities; and (4) understudied topics in domestic and international HIV research, including geographic disparities in infection, innovative interventions to address sexual transmission, and learning how social and behavioral processes interact with epidemiology and pathogen characteristics. We will also enhance dissemination of findings and collaborations among community groups, clinical infectious disease specialists and socio-behavioral researchers. The over-arching aim of the Center will be to enhance interdisciplinary research on HIV and related infectious diseases among drug users. CDUHR will also serve as a resource to disseminate emerging research methods and findings. The Center will provide a research infrastructure for training and consultation to increase productivity and collaboration across investigators, enhance research efficiency and create synergy leading to the development of new investigators, new initiatives and new knowledge in interdisciplinary research. CDUHR-III will achieve these aims through 5 Cores (1) Infectious Diseases - serves as a resource regarding clinical infectious diseases of drug users and related health care issues; (2) Theoretical Synthesis - integrates theories drawn from diverse disciplines; (3) Interdisciplinary Research Methods - fosters excellence in study design and analysis; (4) Dissemination develops dissemination mechanisms for service provider audiences; and (5) Administration - provides scientific leadership and ensuring collaboration and synergy across Cores, projects and investigators.