Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth (iCARE) Plus Effectiveness / Implementation Hybrid Study

遏制尼日利亚青少年艾滋病毒流行的强化组合方法 (iCARE) 加上有效性/实施混合研究

• 批准号: 10749347
• 负责人: Robert Garofalo
• 金额: $ 141.02万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749347
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adherence; Administrator; Adoption; Agreement; Caring; Child Development; Clinic; Clinical Research; Collaborations; Complex; Continuity of Patient Care; Data; Development; Economics; Effectiveness; Epidemic; Exploration, Preparation, Implementation, and Sustainment; Funding; Goals; Government; HIV; HIV Seronegativity; HIV Seropositivity; HIV Seroprevalence; HIV-1; Health; Human Development; Human immunodeficiency virus test; Hybrids; Incidence; Infection; Intervention; Newly Diagnosed; Nigeria; Nigerian; Participant; Phase; Pilot Projects; Population; Preparation; Prevention; Public Health; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Risk; Sampling; Services; Structure; Testing; Vertebral column; Viral; Viral Load result; Youth; adolescent HIV prevention; aged; antiretroviral therapy; care systems; case finding; design; effectiveness outcome; effectiveness research; effectiveness testing; effectiveness/implementation study; effectiveness/implementation trial; evidence base; implementation evaluation; implementation intervention; implementation outcomes; implementation research; implementation science; implementation strategy; improved; improved outcome; individualized medicine; innovation; mHealth; men who have sex with men; motivational enhancement therapy; outcome disparities; peer; performance site; pre-exposure prophylaxis; primary outcome; response; same-sex marriage; secondary outcome; social culture; social stigma; standard of care; success; transgender women; uptake; young men who have sex with men

Project Summary Nigeria has the 4th highest global burden of HIV and an uncontrolled epidemic. Among youth aged 15-24, HIV incidence remains high and rates of viral suppression low. The HIV epidemic in Nigeria's youth is highest in men who have sex with men (MSM) and transgender women (TW). Although external (i.e., non-governmental) funders support key population-focused centers to increase access to HIV services for MSM and TW, their reach is limited by dwindling and unsustainable funding. Efforts to improve the capacity of government clinics to reach and care for young MSM (YMSM) and young TW (YTW) as well as to implement effective, scalable, youth-specific interventions with enhanced prevention, improved case-finding, and increased ART access and adherence support for youth living with HIV (YLH) are critical to turn around lagging indicators across the HIV prevention and care continuum. However, to-date, no interventions have undergone rigorous effectiveness and implementation research in Nigeria's complex sociocultural milieu. iCARE Nigeria is a successful NICHD- funded PATC3H research partnership investigating two youth-specific interventions to improve: (1) HIV case- finding and linkage-to-care among YMSM and YTW, and (2) adherence and viral suppression among largely vertically-infected YLH on ART. Each intervention combines evidence-based peer navigation and mHealth strategies adapted to the local context; feasibility and efficacy were shown in a pilot study (UG3). We herein propose iCARE Plus, to scale out and test effectiveness and implementation outcomes on enhanced versions of the iCARE interventions within the newly formed PATC3H-IN. The iCARE Plus Clinical Research Center (CRC) will conduct hybrid effectiveness-implementation trials that will utilize an EPIS (Exploration, Preparation, Implementation, and Sustainment) framework to contextualize intervention implementation in youth aged 15-24 through new Clinical Research Performance Sites (CRPSs) in HIV “hotspots” across Nigeria's six geopolitically distinct zones. Our specific aims are: Aim 1 (Preparation): Implementation preparation will be carried out at selected government clinics in the HIV hotspots, while increasing their capacity and capability to provide services to YMSM and YTW. Aim 2 (Implementation): Test the effectiveness and implementation outcomes of enhanced versions of the iCARE interventions on: 1) HIV case-finding, linkage-to-care and PrEP uptake among YMSM and YTW and 2) viral load suppression in previously unstudied YLH newly-diagnosed and initiating ART. Aim 3 (Sustainment): Promote sustainment of the iCARE initiative and the implementation science capacity development goals of PATC3H-IN by developing a sustainability plan, including economic considerations that leverage ongoing formative research funded by an NICHD supplement, in collaboration with youth, clinic administrators and health ministries and develop IS capacity, building on our Adolescent HIV Prevention and Treatment Implementation Science Alliance (AHISA)-funded iTRAIN project.

项目总结