Clinical and Translational Science Award (UL1)

这个修订后的应用程序（A2）响应CTSA倡议，建立和维持一个学术社区 临床和转化研究的合作伙伴关系/为了实现这一目标，我们创建了临床研究所， 转化研究（ICTR）建立在成功的相互依赖的计划，包括儿科和成人 患者研究设施，核心实验室，K30临床研究培训计划扩展到包括博士 临床研究，并获得NCRR K12职业发展奖。卢旺达问题国际法庭得到联合国的共同支持， 阿尔伯特·爱因斯坦医学院、叶史瓦大学和蒙蒂菲奥里医学中心，并积极参与 由布朗克斯的140万不同种族的人口组成的社区。卢旺达问题国际法庭还与 区域和附属机构，包括纽约市卫生部，北布朗克斯卫生网络， 临床主任网络，雷曼学院和新罗谢尔护理学院，以扩大研究和 布朗克斯的培训机会CTSA在过去两年的发展过程中， 来自多个学科（包括医学，牙科，护理，流行病学，社会学， 工作和生物医学科学）。在发展爱因斯坦的 2007年战略研究计划，我们1）评估了我们机构内部的障碍，以培养内在的协同作用; 2)启动了建立跨学科研究联系的全机构进程; 3）制定了计划， 巩固支持临床/转化研究的现有基础设施; 4）投资于新的基础设施- 支持CTSA使命的物理设施和项目; 5）统一IRB审查程序; 6） 强调培养和造就一批年轻的研究人员。这个新研究所的合作伙伴共同 提供有形资源，包括一个新的20万nsf遗传和转化医学中心，3万 卢旺达问题国际法庭方案和调查员办公空间、临床研究捐赠基金和配套基金 技术指标包括：（a）化学计量学，（b）生物化学计量学，（c）生物化学计量学，（d）生物化学计量学，（e）生物化学计量学，（f）生物化学计量学 互动资源，包括成人和儿科研究单位; d）社区参与和 合作; e）监管知识和支持; f）生物医学信息学; g）开发;新颖 临床/转化方法学“孵化器”（干细胞研究，生物统计方法学， 行为/社会科学研究和表观基因组学研究）; h）转化技术和资源 (MS分析核心，生物储存库，生物标志物测定核心，翻译遗传学和基因组学资源，以及 细胞治疗实验室）; i）试点和合作项目;以及j）其他关键要素（共享设施 核心和跨学科研究计划）。卢旺达问题国际法庭的使命是加强临床和 通过促进多学科合作，解决研究中的翻译“块”， 提供基础设施和协作支持，加强培训、教育和职业发展。

This revised application (A2) responds to the CTSA initiative to establish and sustain an academic-community partnership for clinical and translational research/To achieve this goal, we created the Institute for Clinical and Translational Research (ICTR) founded on successful inter-dependent programs, including pediatric and adult patient research facilities, core laboratories, a K30 clinical research training program expanded to include a PhD n clinical investigation, and an NCRR K12 award for Career Development. The ICTR is jointly supported by the Albert Einstein College of Medicine, Yeshiva University and Montefiore Medical Center, and actively engages the communities comprising the 1.4 million ethnically diverse population of the Bronx. The ICTR also collaborates with regional and affiliated institutions, including the NYC Department of Health, the North Bronx Health Network, the Clinical Directors Network, Lehman College, and New Rochelle College of Nursing to expand research and training opportunities across the Bronx. The CTSA development process over the past 2 years has engaged a broad array of faculty from a number of disciplines (including medicine, dentistry, nursing, epidemiology, social work, and biomedical sciences) through these transformative partnerships. In parallel with developing Einstein's 2007 Strategic Research Plan, we 1) assessed the barriers within our institutions to cultivate inherent synergies; 2) initiated an Institution-wide process of forging interdisciplinary research linkages; 3) developed plans to consolidate existing infrastructure that supports clinical/translational research; 4) invested in new infrastructure- both physical facilities and programs-that support the CTSA mission; 5) unified the IRB review process; and 6) emphasized the training and nurturing a cohort of young investigators. The partners in this new Institute jointly provide tangible resources, including a new 200,000 nsf Center for Genetic and Translational Medicine, 30,000 nsf of space for ICTR programs and investigators, a joint Clinical ResearchEndowment fund, and matching funds r taondsuCppaorretetraDnesvlaetliopnmaletnet;chbn)olDoegsieigsna, nBdiosscthaotilsatrisc.s,TahnedICRTeRsecaormchpoEntehnicts aRres: oau)rcRe;sce)arPchartEicdipuacantioan,dTrCaliiniincga,l Interaction Resources, including Adult and Pediatric Research Units; d) Community Engagement and Collaboration; e) Regulatory Knowledge and Support; f) Biomedical Informatics; g) Development; Novel Clinical/Translational Methodology "incubators" (Stem Cell Research, Biostatistical Methodologies, Behavioral/Social Science Research, and Epigenomics Research); h) Translational Technologies and Resources (MS Analytic Core, Biorepository, Biomarker Assay Core, Translational Genetics and Genomics Resource, and Cellular Therapeutics Laboratory); i) Pilot & Collaborative Projects; and j) Other key elements (shared facilities and cores, and transdisciplinary research programs). The mission of the ICTR is to enhance clinical and translational research by promoting multidisciplinary collaboration, addressing translational 'blocks' in research, providing infrastructure and collaborative support, and enhancing training, education, and career development.