UPITT Program for Pharmaceutical Outcomes Research in Aging

描述(由申请人提供)：本次K07的总体目标是在UPITT强大的资源基础上建立一个强大的研究和研究培训老龄药物结果研究(PORA)。PORA的具体目标是：1)创建一系列教育，为老年药物结果研究奠定坚实的知识和技能基础；2)在该领域建立一支训练有素的研究人员队伍；以及3)为药物数据的数据管理和分析提供经验学习和支持。为了支持目标一，我们将开发并提供：1)作为临床和翻译科学研究所(CTSI)证书、硕士和博士研究生课程的一部分，设立一个新的老年药学成果研究学分领域；2)每月举办一次老年药学成果研究研讨会；3)每年举办一次客座教授职位；以及4)在美国老年学学会年会上举办老年药学成果研究年度会前研讨会。为了支持目标二，我召集了一群资深和初级教师导师。学员将从多个层面招募(初级教师、博士后研究员、住院医生和博士后学员)，他们来自多个学科，包括药剂学、医学、流行病学、卫生服务研究和其他领域，并得到我们附属医疗保健系统(UPMC和VA)、CTSI、Pepper中心和我们的NIA培训补助金的现有资金支持。我们还将每年提供一个小规模的飞行员奖励。为支持目标三，一名高级生物统计师教员将为上述受训人员提供研究设计和统计支助。由NIA资助的胡椒中心的PI、生物统计学家和PI以及T32和T35项目组成的执行委员会将提供行政和智力领导。PORA将由一个多学科内部咨询委员会监督，以确保PORA与包括CTSI在内的UPITT资源很好地整合和利用。这位候选人是老年药物治疗研究领域的领导者，也是初学者的忠实老师和导师。这项K07提案的长期目标是获得T32和/或中心/计划拨款，以培训未来的研究人员进行重要研究，通过改善药物的安全性和使用来增强老年人的健康。PORA有强有力的机构支持，以确保其短期和长期的成功。相关性(见说明)：老年患者是人口中快速增长的一部分，他们经常经历与药物有关的问题。需要新的研究人员和额外的多学科药物结果研究来发现、更好地了解、预防或减少老年人的药物相关问题。

DESCRIPTION (provided by applicant): The overall goal of this K07 is to build a strong research and research training Pharmaceutical Outcomes Research in Aging (PORA on the strong foundation of resources at UPITT. The PORA specific aims are to: 1) create an educational series that builds a solid foundation of knowledge and skills in geriatric pharmaceutical outcomes research; 2) build a cadre of well trained investigators in the field; and 3) provide experiential learning and support for data management and analysis of pharmaceutical data. In support of aim one, we will develop and provide: 1) a new 9 credit Area of Concentration in Geriatric Pharmaceutical Outcomes Research as part of the Clinical and Translational Science Institute's (CTSI) certificate, masters and PhD graduate programs; 2) a credit bearing monthly geriatric pharmaceutical outcomes research seminar, 3) an annual Visiting Professorship; and 4) an annual pre-meeting workshop on Geriatric Pharmaceutical Outcomes Research at the annual Gerontological Society of America meeting. In support of aim two, I have assembled a group of senior and junior faculty mentors. Trainees will be recruited at multiple levels (junior faculty, post doctoral fellows, residents, and pre-doctoral student trainees), come from multiple disciplines including pharmacy, medicine, epidemiology, health services research and other fields and be supported through existing funding from our affiliated health care systems (UPMC and VA), the CTSI, Pepper Center and our NIA training grants. We will annually also offer a small pilot award. In support of aim three, a senior biostatistician faculty member will provide study design and statistical support for the above- mentioned trainees. An Executive Committee consisting of the PI, the biostatistician and the PI of the NIA- funded Pepper Center and T32 and T35 programs will provide administrative and intellectual leadership. The PORA will be overseen by a multidisciplinary Internal Advisory Committee to assure that the PORA is well integrated with and leverages UPITT resources including the CTSI. The candidate is a leader in the field of geriatric pharmacotherapy research and a committed teacher and mentor to beginning investigators. The long term goal of this K07 proposal is to secure a T32 and/or center/program grant to train future researchers to conduct important research to enhance the health of older adults by improving the safety and use of medications. There is strong institutional support for the PORA to assure its short and long term success. RELEVANCE (See instructions): Older patients represent a rapidly increasing segment of the population that commonly experiences medication-related problems. New investigators and additional multidisciplinary pharmaceutical outcomes research are needed to detect, better understand, prevent or reduce, medication-related problems in older adults.