Development of a Miniature Hydrodynamically Suspended Intrathoracic Tesla Pump

描述(由申请人提供)：这项提案的目标是开发一种微型左心室辅助装置(LVAD)，该装置足够小，可以放置在心尖部的胸腔内。微型泵基于特斯拉原理，将由圆锥形流体动力轴承被动支撑，因此与以前的特斯拉泵设计相比，大大缩小了泵的尺寸。最终的临床系统将由植入的泵、带电池的控制器和经皮能量传输线圈组成。这将是一种完全可植入的系统，使患者能够过上接近正常的生活方式第一代被动悬挂的第一代特斯拉LVAD已经被设计并在体外和体内进行了测试，显示出流量超过12 L/分钟，压力升高90毫米汞，溶血水平低。然而，与目前同时代的LVAD相比，该设备很大。 第一阶段SBIR将实现以下具体目标：1)使用CFD和FEA研究来改进电机设计和系统效率，将流体压力降至最低，并将系统尺寸降至最小。这些研究将具体包括：能够承受轴向和径向负载的锥形流体动力推力轴承的优化；2)完成使用圆锥流体动力轴承的微型特斯拉泵的设计和制造；3)将入口压力传感器和控制器改装到微型特斯拉泵上；以及4)性能测试(HQ)，对微型特斯拉泵进行测试，并进行初始溶血测试。这项拟议的研究旨在证明可以制造小型化的特斯拉泵，并保持或改善较大装置的压力、流量关系和低溶血率。此外，为大型系统开发的压力传感器可以集成到微型特斯拉中，从而提供了一种实现吸力控制的手段。

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a miniaturized Left Ventricular Assist Device (LVAD) that is small enough to be placed in the thoracic cavity at the apex of the heart. The miniature pump is based on the Tesla principal and will be supported passively with conical hydrodynamic bearings, thus greatly reducing the pump size compared to previous Tesla pump designs. The final clinical system will consist of the implanted pump, controller with battery, and transcutaneous energy transmission coil. It will be a completely implantable system allowing the patient a near normal life style A passively suspended first generation Tesla type LVAD has been designed and tested in vitro and in vivo, demonstrating flows above 12 L/min with 90 mmHg pressure rise and low hemolysis levels. However, the device is large compared to current contemporary LVADs. The following specific aims are to be accomplished in this Phase 1 SBIR: 1) Use CFD and FEA studies to improve the motor design and system efficiency, minimize fluid stresses and minimize system size. These studies specifically will include optimization of conical hydrodynamic thrust bearings capable of supporting both axial and radial loads; 2) Complete the design and manufacture of the miniature Tesla pump employing the conical hydrodynamic bearing; 3) Adaptation of an inlet pressure sensor and controller to the miniature Tesla pump; and 4) Performance test (HQ) the miniature Tesla pump and perform initial hemolysis testing. This proposed research is intended to demonstrate that a miniaturized Tesla pump can be manufactured and that the pressure flow relationship and low rate of hemolysis of the larger device are maintained or improved. In addition, a pressure sensor that has been developed for the larger system can be incorporated in the miniature Tesla, thereby providing a means for implementing suction control.