Automated Device for High Throughput Cell Cryopreservation

描述(申请人提供)：“培养细胞”已成为生物技术和生物医学各个领域研究成果翻译的关键环节。现在，生物制药、癌症研究、细胞和基因治疗以及干细胞研究的增长推动了对培养细胞产品需求的空前增长。这些行业现在依赖过时的、小批量的非标准化技术来存储其关键蜂窝工具的日常生产中的细胞。CPSI Biotech正在开发一种创新的可控速率冷冻设备RapidCP“，旨在快速冷冻生物样本，同时保持样本的质量和功能。这一阶段的提案专注于开发一种创新的研究/细胞处理设备RapidCP”-一种旨在实现高通量冷冻样本的设备，应用于生物加工、细胞治疗、药物发现和基础科学领域。此外，该技术的设计将允许多个独立的冷却块，从而允许连续处理可管理的批量。这将减少样品积压，缓解时间限制，并允许更有效地处理样品。这项建议代表了产品开发、耦合工程和生命科学的综合方法。 与公共健康相关：这项提议旨在开发一种快速冷冻保存设备，该设备比目前的仪器和方案更有效地冷冻保存细胞。已经开发了一个原型装置，初步数据支持这样一种理论，即这种装置可以被开发出来，并引起各种感兴趣的各方的兴趣。

DESCRIPTION (provided by applicant): The "cultured cell" has emerged as a critical link in the translation of research in the various fields of biotechnology and biomedicine. An unprecedented increase in the demand for cultured cell products is now driven by the growth in biopharmaceuticals, cancer research, cell and gene therapy and stem cell research. These industries now rely on dated, low-volume, non-standardized technologies to bank cells in the daily production of their critical cellular tool. CPSI Biotech is developing an innovative controlled rate freezing device, RapidCP", designed to rapidly freeze biological samples while maintaining sample quality and functionality. This Phase 1 proposal focuses on the development of an innovative research/ cell processing device, RapidCP" - a device designed to enable the high throughput freezing of samples for application in the bioprocessing, cell therapy, drug discovery, and basic sciences arena. Further, the design of the technology will allow for multiple independent cooling blocks thereby allowing for continuous processing of manageable lot sizes. This will reduce sample backlog, alleviate time constraints and allow more effective sample processing. This proposal represents an integrative approach to product development coupling engineering, and life sciences PUBLIC HEALTH RELEVANCE: This proposal is designed to develop a rapid cryopreservation device that more effectively cryopreserves cells than current instruments and protocols. A prototype device has already been developed and the preliminary data support the theory that such a device can be developed and be of interest to a variety of interested parties.