Aperio ScanScope XT Digital Slide Scanner System

描述（由申请人提供）：肯塔基州大学拟购买Aperio ScanScope（R）XT数字载玻片扫描仪，包括ImageScope”/Genie”和Webscope”查看软件。该仪器将放置在肯塔基州大学阿尔茨海默病中心神经病理学核心实验室。该位置是安全的，但开放给所有的主要和次要用户，与优秀的机构支持。11个主要用户和3个次要用户，代表大学内的10个不同的学术部门，强烈希望该仪器。目前在肯塔基州大学内或附近没有类似的仪器;然而，这一科学进步与肯塔基州大学现有的医学专业知识、技术基础设施和研究设施非常吻合。Aperio ScanScope XT以数字化格式扫描和分析显微镜载玻片，从而实现组织病理学数据的优化和详细存档和数据挖掘。除了正常结构之外，该仪器还促进了ND组织病理学特征的数字化识别和分析，代表了定量神经病理学领域的重大技术进步。此外，载玻片扫描仪是体视学、原位杂交信号定量、动物模型评估（包括脑创伤和朊病毒疾病模型）和其他尖端应用中改进存活细胞计数定量测量的理想选择，这些应用将直接促进肯塔基州大学主要用户的NIH资助研究项目。该仪器将提供一个独特的机会，介绍，验证和发布数字显微镜和生物信息学方法，以量化大脑病理学。该工具将有一个基础广泛的咨询小组，由来自肯塔基州大学的八个不同学术部门代表。最后，由于其基于网络的功能，购买Aperio ScanScope XT将允许在整个肯塔基州的偏远地区和通过全国阿尔茨海默病中心网络交换数据。

DESCRIPTION (provided by applicant): The University of Kentucky proposes to acquire an Aperio ScanScope(R) XT digital slide scanner including the ImageScope"/Genie" and Webscope" viewing software. This instrument will be housed in the University of Kentucky Alzheimer's Disease Center Neuropathology Core laboratory. The location is safe and secure, but open to all the Major and Minor Users, with outstanding Institutional Support. 11 Major Users and 3 Minor Users, representing ten different academic departments within the University, strongly desire the instrument. There is no analogous instrument currently available within or nearby the University of Kentucky; however, this scientific advancement dovetails very well with existing medical expertise, technical infrastructure, and research facilities at the University of Kentucky. The Aperio ScanScope XT scans and analyzes microscope slides in a digitized format that will enable optimized and detailed archiving and data mining of histopathological data. The instrument represents a significant technological step forward for the field of quantitative neuropathology by facilitating the digitized identification and analysis of histopathological hallmarks of ND, in addition to normal structures. In addition, the slide scanner is ideal for improving quantitative measures of surviving cell counts in stereology, in situ hybridization signal quantification, animal model assessments (including brain trauma and prion disease models), and other cutting edge applications that will directly facilitate NIH-funded research projects by Major Users at the University of Kentucky. This instrument will provide a unique opportunity to introduce, validate, and publish methods in digital microscopy and bioinformatics for the purpose of quantifying brain pathology. The instrument will have an Advisory Panel that is broad-based, with representation by eight different academic departments from the University of Kentucky. Finally, due to its web-based functionality, the purchase of the Aperio ScanScope XT will allow for the exchange of data throughout Kentucky's remote regions and through the network of Alzheimer's Disease Centers nationally.