SPORE in Skin Cancer

匹兹堡大学和匹兹堡大学癌症研究所提议在皮肤癌方面开展一项专门的卓越研究计划(孢子)。匹兹堡大学皮肤癌孢子中心的总体目标是提高皮肤癌的检测和治疗水平。孢子计划将包括六个皮肤癌翻译研究项目，四个核心，包括一个行政核心，一个发展研究计划和一个职业发展计划。匹兹堡大学皮肤癌孢子中心将使用跨学科的方法来实现其目标，与基础、应用和临床科学的合作研究人员一起开展项目。它也是器官特有的，因为它的方法和所有项目都将测试关于皮肤癌生物学、敏感性、检测或治疗的假设。长期转化性研究项目，将作为改善皮肤癌患者预后的基础。这六个主要项目包括：(1)萝卜硫素预防黑色素瘤；(2)多重抗原工程树突状细胞免疫和干扰素？促进转移性黑色素瘤；(3)极化树突状细胞引导黑色素瘤特异性反应；(4)针对黑色素瘤及其肿瘤相关血管表达的EphA2的治疗性免疫靶向；(5)描绘影响烷化剂治疗黑色素瘤疗效的DNA修复途径；(6)通过T-regs耗尽加强基于树突状细胞的免疫疗法治疗Sezary综合征。四个研究核心将密切互动，协助主要研究项目、发展研究项目和职业发展调查人员开展转化性皮肤癌研究。研究核心是：核心A行政核心；核心B组织核心；核心C免疫监测和细胞产品实验室(IMCPL)；核心D生物静力学。行政核心将征求内部和外部科学咨询委员会的反馈，并为孢子计划提供科学、监管和财政监督。皮肤孢子调查人员将共同努力，协同实现该计划的目标，并将与其他机构的孢子调查人员互动，以改善皮肤癌患者的预后。

The University of Pittsburgh and University of Pittsburgh Cancer Institute propose to conduct a Specialized Program of Research Excellence (SPORE) in Skin Cancer. The overall goals of the University Pittsburgh Skin Cancer SPORE are to improve the detection and treatment of skin cancer. The SPORE program will consist of six translational research projects in skin cancer, four cores including an administrative core, a developmental research program and a career development program. The University of Pittsburgh Skin Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co- investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about skin cancer biology, susceptibility, detection, or treatment. The long-term translational research projects that will serve as the basis for improving the outcome of patients diagnosed with skin cancer. The six main projects include: (1) Chemoprevention of Melanoma with Sulforaphane; (2) Multiple Antigen-Engineered DC Immunization and IFN? Boost for Metastatic Melanoma; (3) Polarized Dendritic Cells Guide Melanoma-Specific Responses; (4) Therapeutic Immune Targeting of EphA2 Expressed by Melanoma and Its Tumor-Associated Vasculature; (5) Delineating the DNA Repair pathways impacting alkylating agent efficacy in the treatment of Melanoma; (6) Augmentation of Dendritic Cell-based Immunotherapy for Sezary Syndrome by T-regs depletion. The four research cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational skin cancer research. The research cores are: Core A. Administrative Core; Core B. Tissue Core; Core C. Immunological Monitoring and Cellular Products Laboratory (IMCPL); Core D. Biostatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Skin SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with skin cancer.