Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer

这项申请是达纳-法伯/哈佛癌症中心(DF/HCC)肺癌专门研究项目(孢子)的竞争性更新。达纳-法伯/哈佛癌症中心肺癌孢子包括来自波士顿哈佛附属医院、哈佛医学院和哈佛公共卫生学院的研究人员。这个DF/HCC肺癌孢子将建立在DF/HCC内正在进行的科学研究的基础上。提出了五大项目。项目1将使用胚系DNA中的单核苷酸多态来检查它们与非小细胞肺癌治疗后患者预后的关系。项目2将研究转录因子Foxa2和C/EBP家族成员在肺癌发病机制和潜在治疗中的作用。项目3计划用其他酪氨酸激酶抑制剂和放射来靶向对厄洛替尼耐药的肺癌，以提供有关靶向药物有效组合的进一步信息。项目4将描述Hsp90抑制剂在具有不同基因组变化的非小细胞肺癌中的作用，以帮助识别可能从这种疗法中受益的患者。项目5将研究肺癌患者对表皮生长因子受体靶向药物的获得性耐药的细胞系和人体试验的机制。2003年建立的4个核心整合了这些项目。这些核心包括1)组织和病理学核心，2)管理、评估和规划核心，3)生物统计学核心，4)基因组学和生物信息学核心。这个孢子应用程序描述了一个发展研究计划，其中包括我们过去的业绩和选择新项目的计划。职业发展计划描述了我们的接受者，并概述了识别和支持肺癌领域有才华的年轻研究人员的机制。发展研究和职业发展计划将为社区参与DF/HCC肺癌孢子的规划和财务支持提供重点。DF/HCC肺癌孢子的目标是继续将生物和技术进步转化为对肺癌患者和肺癌风险患者具有临床意义的进步。

This application is a competitive renewal of the Dana-Farber/Harvard Cancer Center (DF/HCC) Lung Cancer Specialized Program in Research Excellence (SPORE). The Dana-Farber/Harvard Cancer Center Lung Cancer SPORE includes investigators from the Harvard-affiliated hospitals in Boston, Harvard Medical School, and the Harvard School of Public Health. This DF/HCC Lung Cancer SPORE will build on the strengths of established ongoing scientific investigation within the DF/HCC. Five major projects are proposed. Project 1 will use single nucleotide polymorphisms in germline DMA to examine their associations with patient outcome following treatment for non-small cell lung cancer. Project 2 will examine the transcription factors Foxa2 and the C/EBP family members in the pathogenesis and potential treatment of lung cancer. Project 3 plans to target erlotinib-resistant lung cancer with other tyrosine kinase inhibitors and irradiation to provide further information on effective combinations of targeted agents. Project 4 will characterize the effect of Hsp90 inhibitors in NSCLCs with different genomic changes to help identify patients who may benefit from this therapy. Project 5 will study the mechanisms of acquired resistance to epidermal growth factor receptor-targeted agents in cell lines and human trials for patients with lung cancer. The 4 cores established in 2003 integrate these Projects. These include 1) Tissue and Pathology Core, 2) Administration, Evaluation and Planning Core, 3) Biostatistics Core, 4) Genomics and Bioinformatics Core. This SPORE application describes a Development Research Program that includes our past performance and plan for selection of new projects. The Career Development Program describes our recipients and outlines the mechanism for the identification and support of talented young investigators in lung cancer. The Developmental Research and Career Development Programs will provide the focus for involvement of the community in planning and financial support of the DF/HCC Lung Cancer SPORE. The goal of the DF/HCC Lung Cancer SPORE is to continue the translation of biological and technological advances into clinically meaningful advances for patients with lung cancer and at risk for lung cancer.