H-19197 PHACS PH 200 ADOLESCENT MASTER PROTOCOL (AMP)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 这是一项前瞻性队列研究，旨在确定艾滋病毒感染和抗逆转录病毒治疗对青春期前和青少年围产期艾滋病毒感染的影响。将招募一组来自相似社会人口学背景和年龄分布的围产期暴露于HIV的未感染HIV的儿童进行比较。 研究领域包括生长和性成熟、心血管疾病的代谢风险因素、心脏功能、骨骼健康、神经系统、神经发育、语言、听力和行为功能以及人乳头瘤病毒（HPV）感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy on pre-adolescents and adolescents with perinatal HIV infection. A group of HIV-uninfected children with perinatal exposure to HIV from a similar sociodemographic background and age distribution will be enrolled for comparison. Domains to be investigated include growth and sexual maturation, metabolic risk factors for cardiovascular disease, cardiac function, bone health, neurologic, neurodevelopment, language, hearing and behavioral function, and human papillomavirus (HPV) infection.