CLINICAL CORE C

临床核心C的目标是： 1.为项目1、2和3的临床部分提供一个中央实验室，以招募和鉴定正常和哮喘受试者。 2.为肺功能测试、抗原皮肤测试和乙酰甲胆碱激发的性能和质量控制提供中央设施。 3.提供一个中央实验室，收集和分析支气管肺泡灌洗液和活检组织。 4.协调项目1、2和3中的研究人员的支气管肺泡灌洗液细胞和液体以及活检组织的分布。 5.协调关于正常受试者和哮喘患者的所有临床和实验室数据的数据库开发，并将数据传递给个别调查人员。 6.促进项目间就临床结果和技术成果进行沟通。 在这样做的过程中，该计划项目赠款的临床方面将以高标准发挥作用。

The objectives of the Clinical Core C are: 1. To provide a central laboratory for the recruitment and characterization of normal and asthmatic subjects for the clinical components of Projects 1, 2, and 3. 2. To provide a central facility for performance and quality control of pulmonary function testing, antigen skin testing, and methacholine challenge. 3. To provide a central laboratory for collection and analysis of bronchoalveolar lavage fluid and biopsy tissue. 4. To coordinate the distribution of bronchoalveolar lavage cells and fluid, and biopsy tissue to the investigators in Projects 1, 2, and 3. 5. To coordinate the database development of all clinical and laboratory data on normal subjects and patients with asthma as well as transmittal of the data to the individual investigators. 6. To facilitate interproject communication concerning both clinical findings and technical accomplishments. In doing so, the clinical aspects of this Program Project grant will function at a high standard.