CART PEPTIDES IN AROUSAL AND SLEEP

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 初步数据表明，CART肽影响睡眠。 因此启动了本研究。 icv注射CART 55-102对促进觉醒的作用是稳健的，并且在注射后持续长达4小时。用无活性的CART片段CART 1-27未观察到该效果。 此外，觉醒期之后，NREM和REM睡眠都出现了反弹性增加。 这些发现指出了CART在调节觉醒方面的潜在新作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Preliminary data suggested that CART peptides influenced sleep. Therefore this study was initiated. The effect of icv injection of CART 55-102 on promoting wakefulness was robust and lasted for up for 4 hours after injection. The effect was not seen with an inactive CART fragment, CART 1-27. Moreover, the period of wakefulness was followed by a rebound increase in both NREM and REM sleep. These findings point to a potential novel role for CART in regulating wakefulness.