CART PEPTIDES IN AROUSAL AND SLEEP

车肽在唤醒和睡眠中的作用

• 批准号: 7958285
• 负责人: DAVID B RYE
• 金额: $ 2.75万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958285
• 关键词: Arousal; Brain; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hour; Injection of therapeutic agent; Institution; Measures; Primates; Rattus; Research; Research Personnel; Resources; Role; Sleep; Source; United States National Institutes of Health; Wakefulness; cocaine- and amphetamine-regulated transcript protein; novel; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of preliminary studies that showed that injection of CART peptide into the brain prevented sleep, a more detailed study of this effect was needed. Accordingly, rats were injected with CART peptide and sleep was measured electrophysiologically. Wakefulness was quantified from the somnogram. The effect of icv injection of CART 55-102 on promoting wakefulness was robust and lasted for up for 4 hours following injection. These findings point to a potential novel role for CART in regulating wakefulness.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于初步研究表明，将CART肽注射到大脑中会阻止睡眠，因此需要对这种影响进行更详细的研究。 因此，给大鼠注射CART肽，并在电生理学上测量睡眠。 从睡眠图中量化觉醒。 icv注射CART 55-102对促进觉醒的作用是稳健的，并且在注射后持续长达4小时。这些发现指出了CART在调节觉醒方面的潜在新作用。