ASSESSMENT OF CRH RECEPTOR ANTAGONIST FOR SELF-INJURIOUS BEHAVIOR IN MACAQUES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 自伤行为是生活在生物医学研究设施中的恒河猴最棘手的临床症状之一，目前的治疗方法往往无效。本研究最初旨在评价CRH 1受体拮抗剂在减少圈养恒河猴自伤行为（SIB）中的疗效。 在研究的早期阶段，初步数据表明CRH 1受体拮抗剂持续增加猴子的皮质醇水平。 基于这一意外的发现，我们决定放弃CRH拮抗剂治疗，以避免症状加重，而是专注于替代疗法。 我们目前正在评估治疗自伤和刻板行为与抗焦虑丁螺环酮。已收集了8只动物的数据，我们正在确定另外2只动物用于研究。 初步结果在美国灵长类动物学会2010年年会上公布。 这项研究的数据有可能极大地影响我们中心和其他生物医学研究机构的恒河猴的临床健康，改善动物福利并进行高质量的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Self-injurious behavior is one of the most troublesome clinical conditions in rhesus monkeys housed in biomedical research facilities, for which current treatment methods are often ineffective. This study was originally designed to evaluate the efficacy of a CRH1 receptor antagonist in reducing self-injurious behavior (SIB) in captive housed rhesus macaques. During the early part of the study, preliminary data indicated that the CRH1 receptor antagonist consistently increased cortisol levels in monkeys. Based on this unexpected finding, we decided to forgo treatment with the CRH antagonist to avoid exacerbating symptoms and instead focus on alternative therapies. We are currently evaluating treatment for self-injurious and stereotypical behavior with the anxiolytic buspirone. Data has been collected from 8 animals and we are in the process of identifying an additional 2 animals for study. Preliminary results were presented at the American Society of Primatologists 2010 annual meeting. Data from this study has the potential to greatly impact the clinical health of rhesus monkeys both at our center and at other biomedical research facilities, improving animal welfare and allowing for quality research.